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What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

By mouth

Prevents bleeding problems by helping blood clot better… Read more

Brand names include: K1-1000, Mephyton


Prevents bleeding problems by helping blood clot better… Read more

Brand names include: Aquamephyton

Drug classes About this
Nutriceutical, Nutritive Agent

What works? Research summarized

Evidence reviews

Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis

This review examined the efficacy of vitamin K in treating excessive anticoagulation. The authors concluded that the limited evidence available suggests that oral or intravenous, but not subcutaneous, vitamin K are more effective than withholding anticoagulation therapy. The methods employed to combine the studies were inappropriate, thus it is impossible to determine whether these conclusions are reliable.

Venous Thromboembolic Diseases: The Management of Venous Thromboembolic Diseases and the Role of Thrombophilia Testing [Internet]

Venous thromboembolism (VTE) is a condition in which a blood clot (a thrombus) forms in a vein and then dislodges to travel in the blood (an embolus). A venous thrombus most commonly occurs in the deep veins of the legs or pelvis; this is then called a deep vein thrombosis (DVT). Blood flow through the affected vein can be limited by the clot, and it can cause swelling and pain in the leg. If it dislodges and travels to the lungs, to the pulmonary arteries, it is called a pulmonary embolism (PE), which in some cases may be fatal. VTE as a term includes both DVT and PE. Major risk factors for VTE include a prior history of DVT, age over 60 years, surgery, obesity, prolonged travel, acute medical illness, cancer, immobility, thrombophilia (an abnormal tendency for the blood to clot) and pregnancy.

Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials

This review investigated the effects of oral vitamin K supplements on bone mineral density and fractures. The authors concluded that supplementation may reduce bone loss and that an effect on fractures has been shown in Japanese patients. The cautious conclusions reflect the limitations of the available evidence and appear appropriate.

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