Home > Drugs A – Z > Methylphenidate
  • We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Methylphenidate

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Absorbed through the skin

Methylphenidate transdermal is used to treat attention deficit hyperactivity disorder (ADHD). It belongs to the group of medicines called central nervous… Read more

Brand names include: Daytrana

By mouth

Methylphenidate is used to treat attention deficit hyperactivity disorder (ADHD). It belongs to the group of medicines called central nervous system (CNS)… Read more

Brand names include: Concerta, Metadate CD

Drug classes About this
CNS Stimulant, Central Nervous System Agent

What works? Research summarized

Evidence reviews

Core ADHD symptom improvement with atomoxetine versus methylphenidate: a direct comparison meta-analysis

Bibliographic details: Hazell PL, Kohn MR, Dickson R, Walton RJ, Granger RE, Wyk GW.  Core ADHD symptom improvement with atomoxetine versus methylphenidate: a direct comparison meta-analysis. Journal of Attention Disorders 2011; 15(8): 674-683 Available from: http://jad.sagepub.com/content/15/8/674.abstract

A meta-analyses comparing atomoxetine with methylphenidate for treatment of children with attention-deficit/hyperactivity disorder

Bibliographic details: Xv PR, Fang ZM.  A meta-analyses comparing atomoxetine with methylphenidate for treatment of children with attention-deficit/hyperactivity disorder. Chinese Journal of Evidence-Based Medicine 2009; 9(3): 346-349 Available from: http://www.cjebm.org.cn/oa/DArticle.aspx?type=view&id=090318

A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents

This review concluded that drug treatment was more effective than no drug treatment, but there was insufficient evidence to compare different drugs for effectiveness or safety. This was a well-conducted review and the authors' conclusions are likely to be reliable.

See all (87)

Summaries for consumers

Treatment Options for ADHD in Children and Teens: A Review of Research for Parents and Caregivers

This summary discusses the different types of treatment for ADHD. It explains what research says about how each treatment improves symptoms and the risks involved with each treatment. It can help you talk with the doctor about ADHD and your child.

Ritalin for adult attention deficit hyperactivity disorder (ADHD)

Symptoms of attention deficit hyperactivity disorder (ADHD), diagnosed mainly in children, often persist into adulthood, afflicting 1% to 6% of the general population. Adults with ADHD have higher rates of other psychiatric problems and functional difficulties in a number of key areas such as academic achievement, interpersonal relationships, employment, and driving performance.

Medications for Attention Deficit Hyperactivity Disorder in children with tics

As many as half of all children with tic disorders also have Attention Deficit Hyperactivity Disorder (ADHD). Symptoms of ADHD are often more disabling for children than their tics. Historically, the reported ability of stimulant medications to worsen tics has limited their use in children who have both a chronic tic disorder and ADHD. To evaluate evidence for this reported phenomenon we searched for clinical trials of medications for ADHD used specifically in children with tic disorders. The trials indicate that a number of stimulant and non‐stimulant medications are safe and effective treatments for ADHD symptoms and do not worsen tics. High dose stimulants may transiently worsen tics in some children, and worsening tics may limit dose increases of stimulants in some children, but in the majority of children both tics and ADHD symptoms improve with use of stimulant medications.

See all (15)

PubMed Health Blog...

read all...