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What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

By mouth

Dolasetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation. Dolasetron works to block the signals… Read more

Brand names include: Anzemet


Dolasetron injection is used to prevent and treat nausea and vomiting that may happen after surgery. This medicine is available only with your doctor's… Read more

Brand names include: Anzemet

Drug classes About this

What works? Research summarized

Evidence reviews

Drug Class Review: Newer Antiemetics: Final Report Update 1 [Internet]

Nausea and vomiting are major concerns for patients undergoing chemotherapy, radiation therapy and surgery with general anesthesia. Risk factors associated with chemotherapy-induced nausea and vomiting include emetogenicity of the chemotherapy regimen, dose, speed of intravenous infusion, female gender, age under 50 years, history of ethanol consumption, and history of prior chemotherapy. Factors predictive of radiation therapy-induced nausea and vomiting include site of irradiation (in particular, total body irradiation and radiation fields that include the abdomen), total field size, dose per fraction, age, and predisposition for emesis (history of sickness during pregnancy or motion sickness). Female gender, a history of motion sickness or prior postoperative nausea and vomiting, nonsmoking status, and use of postoperative opioids have been suggested as factors predictive of postoperative nausea and vomiting. The objective of this review was to evaluate the comparative effectiveness and harms of newer antiemetic drugs including the 5-HT3 and NK-1 antagonists.

Dementia: A NICE-SCIE Guideline on Supporting People With Dementia and Their Carers in Health and Social Care

This guideline has been developed to advise on supporting people with dementia and their carers in health and social care. The guideline recommendations have been developed by a multidisciplinary team of health and social care professionals, a person with dementia, carers and guideline methodologists after careful consideration of the best available evidence. It is intended that the guideline will be useful to practitioners and service commissioners in providing and planning high-quality care for those with dementia while also emphasising the importance of the experience of care for people with dementia and carers.

A network meta-analysis on the efficacy of serotonin type 3 receptor antagonists used in adults during the first 24 hours for postoperative nausea and vomiting prophylaxis

The review found than dolasetron, granisetron, ondansetron and tropisetron were all more effective than placebo at preventing post-operative nausea and vomiting. Granisetron may be more effective than dolasetron, or ondansetron. The review was not well reported, but the large number of trials identified means that the results of the comparisons with placebo are likely to be reliable.

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Summaries for consumers

Comparing Newer Antiemetics

How do newer antiemetics compare in in adults?

Drugs for preventing nausea and vomiting after surgery

We found eight drugs that reliably prevented nausea or vomiting after surgery. The drugs prevented nausea or vomiting in three or four people out of every 10 who would have vomited or felt nauseated with a placebo. We did not find reliable evidence that one drug was better than another. A person's age or sex, the type of surgery, or the time the drug was given did not change the effect of a drug. When drugs were given together, their effects simply added. Side effects were mild and affected four out of 100 people for the two drugs most studied.

Nausea and Vomiting (PDQ®): Patient Version

Expert-reviewed information summary about nausea and vomiting as complications of cancer or its treatment. Approaches to the management of nausea and vomiting are discussed.

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