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Chlorothiazide

What works?

Learn more about the effects of these drugs. The most reliable research is summed up for you in our featured article.

Injection

Chlorothiazide is used to treat fluid retention (edema) that is caused by congestive heart failure, severe liver disease (cirrhosis), kidney disease,… Read more

Brand names include: Diuril Sodium, PremierPro RX Chlorothiazide Sodium

By mouth

Chlorothiazide is used to treat fluid retention (edema) that is caused by congestive heart failure, severe liver disease (cirrhosis), kidney disease,… Read more

Brand names include: Diuril

Drug classes About this
Cardiovascular Agent

What works? Research summarized

Evidence reviews

Dementia: A NICE-SCIE Guideline on Supporting People With Dementia and Their Carers in Health and Social Care

This guideline has been developed to advise on supporting people with dementia and their carers in health and social care. The guideline recommendations have been developed by a multidisciplinary team of health and social care professionals, a person with dementia, carers and guideline methodologists after careful consideration of the best available evidence. It is intended that the guideline will be useful to practitioners and service commissioners in providing and planning high-quality care for those with dementia while also emphasising the importance of the experience of care for people with dementia and carers.

Hypertension in Pregnancy: The Management of Hypertensive Disorders During Pregnancy

This clinical guideline concerns the management of hypertensive disorders in pregnancy and their complications from preconception to the postnatal period. For the purpose of this guideline, ‘pregnancy’ includes the antenatal, intrapartum and postpartum (6 weeks after birth) periods. The guideline has been developed with the aim of providing guidance in the following areas: information and advice for women who have chronic hypertension and are pregnant or planning to become pregnant; information and advice for women who are pregnant and at increased risk of developing hypertensive disorders of pregnancy; management of pregnancy with chronic hypertension; management of pregnancy in women with gestational hypertension; management of pregnancy for women with pre-eclampsia before admission to critical care level 2 setting; management of pre-eclampsia and its complications in a critical care setting; information, advice and support for women and healthcare professionals after discharge to primary care following a pregnancy complicated by hypertension; care of the fetus during pregnancy complicated by a hypertensive disorder.

Diuretics for heart failure in adults

Chronic heart failure (CHF) (also called congestive heart failure, cardiac and heart failure) is a disorder in which the heart loses its ability to pump blood efficiently throughout the body. The oxygen and nutrients in the blood provide the body with the energy it needs to operate efficiently. CHF causes breathlessness and fatigue because the heart cannot function as it should. Heart failure may affect the left, right, or both sides of the heart. If the left half of the heart fails, fluid will build up in the lungs due to congestion of the veins of the lungs. If the left half of the heart fails, general body vein pressure will increase and fluid will accumulate in the body, especially the tissues of the legs and abdominal organs. Often left heart failure leads to right heart failure causing biventricular failure. Fluid may build up in the lungs and legs. Coronary artery disease, a heart attack, or high blood pressure are some of the causes of heart failure. Drug treatments include digitalis, angiotensin‐converting enzyme (ACE) inhibitors, beta‐blockers and diuretics. Diuretics are important as they relieve symptoms quickly and control fluid retention. Some of the diuretics used are furosemide, bumetanide and chlorothiazide. The available data from several small controlled trials show that in patients with CHF, conventional diuretics appear to reduce the risk of death and worsening heart failure when compared to an inactive sugar pill (placebo). About 80 deaths may be avoided for every 1000 people treated. Diuretics also increase the ability to exercise, by about 28% to 33% more than with other active drugs. These conclusions were based on 14 controlled trials (525 people), of which three trials noted deaths in 202 people randomised to receive either diuretic or placebo, and two trials, a total of 169 people, looked at hospitalisation for worsening heart failure. Of the seven trials comparing diuretic treatment with another drug, the effects on exercise were studied in four trials where 91 people were randomised to receive either a diuretic or an ACE inhibitor or digoxin. Most of the trials had small numbers and lasted from 4 to 24 weeks, a short time for a chronic disease. The age of the participants was 59 years, which is relatively young, and the use of diuretic drug was not standardised across the studies. More research would be needed to further confirm the long term benefits of diuretic treatment for CHF patients because these studies were small.

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Summaries for consumers

Diuretics for heart failure in adults

Chronic heart failure (CHF) (also called congestive heart failure, cardiac and heart failure) is a disorder in which the heart loses its ability to pump blood efficiently throughout the body. The oxygen and nutrients in the blood provide the body with the energy it needs to operate efficiently. CHF causes breathlessness and fatigue because the heart cannot function as it should. Heart failure may affect the left, right, or both sides of the heart. If the left half of the heart fails, fluid will build up in the lungs due to congestion of the veins of the lungs. If the left half of the heart fails, general body vein pressure will increase and fluid will accumulate in the body, especially the tissues of the legs and abdominal organs. Often left heart failure leads to right heart failure causing biventricular failure. Fluid may build up in the lungs and legs. Coronary artery disease, a heart attack, or high blood pressure are some of the causes of heart failure. Drug treatments include digitalis, angiotensin‐converting enzyme (ACE) inhibitors, beta‐blockers and diuretics. Diuretics are important as they relieve symptoms quickly and control fluid retention. Some of the diuretics used are furosemide, bumetanide and chlorothiazide. The available data from several small controlled trials show that in patients with CHF, conventional diuretics appear to reduce the risk of death and worsening heart failure when compared to an inactive sugar pill (placebo). About 80 deaths may be avoided for every 1000 people treated. Diuretics also increase the ability to exercise, by about 28% to 33% more than with other active drugs. These conclusions were based on 14 controlled trials (525 people), of which three trials noted deaths in 202 people randomised to receive either diuretic or placebo, and two trials, a total of 169 people, looked at hospitalisation for worsening heart failure. Of the seven trials comparing diuretic treatment with another drug, the effects on exercise were studied in four trials where 91 people were randomised to receive either a diuretic or an ACE inhibitor or digoxin. Most of the trials had small numbers and lasted from 4 to 24 weeks, a short time for a chronic disease. The age of the participants was 59 years, which is relatively young, and the use of diuretic drug was not standardised across the studies. More research would be needed to further confirm the long term benefits of diuretic treatment for CHF patients because these studies were small.

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