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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].
Show detailsBibliographic details: Zeng C, Zhou H, Wei Y, Wang L, Xie H, Yao W. Chemotherapy with or without irinotecan in patients with advanced or recurrent gastric cancer: a meta-analysis of randomized controlled trials. Chinese Medical Journal 2014; 127(5): 951-956. [PubMed: 24571893]
Abstract
BACKGROUND: Studies have shown that irinotecan can improve survival in patients with advanced or recurrent gastric cancer, but the overall benefit of irinotecan in the treatment of advanced or recurrent gastric cancer remains controversial. The aim of this study was to evaluate the benefits and risks of irinotecan for survival in patients with advanced or recurrent gastric cancer. Method We searched PubMed, EmBase, the Cochrane Central Register of Controlled Trials, reference lists of articles, and proceedings of major conferences for relevant clinical trials. We included randomized controlled trials that reported on the efficacy and safety of irinotecan in patients with advanced or recurrent gastric cancer. Outcomes were analyzed by survival rate, objective response rate (ORR), and toxicity. Furthermore, the analysis was further stratified by factors that could affect the treatment effects.
RESULTS: Eight trials recruiting 1 546 patients with advanced or recurrent gastric cancer were included in the analysis. Overall, irinotecan therapy was associated with a 6% improvement in survival rate, but this difference was not statistically significant (odds ratio (OR) 0.94; 95% confidence interval (95% CI) 0.70-1.27; P = 0.69). However, irinotecan therapy had more frequent ORR than irinotecan-free arm (OR 1.70; 95% CI 1.34-2.17; P < 0.001). Furthermore, irinotecan therapy was associated with a clinically and statistically significant increase in the risk for declined hemoglobin, hyponatremia, and diarrhea, but it also protected against thrombocytopenia risk when compared with irinotecan-free therapy.
CONCLUSIONS: There is no evidence to support the use of irinotecan therapy in patients with advanced or recurrent gastric cancer; however, given the significant advantage in ORR irinotecan therapy using combination regimens may be considered for further evaluation in subsets of patients who may benefit from this treatment.
- Irinotecan-involved regimens for advanced gastric cancer: a pooled-analysis of clinical trials.[World J Gastroenterol. 2010]Irinotecan-involved regimens for advanced gastric cancer: a pooled-analysis of clinical trials.Wang DL, Gu DY, Huang HY, Xu Z, Chen JF. World J Gastroenterol. 2010 Dec 14; 16(46):5889-94.
- Irinotecan Monotherapy Versus Irinotecan-Based Combination as Second-Line Chemotherapy in Advanced Gastric Cancer: A Meta-Analysis.[Cancer Res Treat. 2017]Irinotecan Monotherapy Versus Irinotecan-Based Combination as Second-Line Chemotherapy in Advanced Gastric Cancer: A Meta-Analysis.Cho YH, Yoon SY, Kim SN. Cancer Res Treat. 2017 Jan; 49(1):255-262. Epub 2016 May 18.
- Randomized phase II trial of first-line treatment with tailored irinotecan and S-1 therapy versus S-1 monotherapy for advanced or recurrent gastric carcinoma (JFMC31-0301).[Anticancer Drugs. 2011]Randomized phase II trial of first-line treatment with tailored irinotecan and S-1 therapy versus S-1 monotherapy for advanced or recurrent gastric carcinoma (JFMC31-0301).Komatsu Y, Takahashi Y, Kimura Y, Oda H, Tajima Y, Tamura S, Sakurai J, Wakasugi T, Tatebe S, Takahashi M, et al. Anticancer Drugs. 2011 Jul; 22(6):576-83.
- Review Irinotecan-containing doublet treatment versus irinotecan monotherapy as second-line choice for advanced gastric cancer.[BMC Gastroenterol. 2018]Review Irinotecan-containing doublet treatment versus irinotecan monotherapy as second-line choice for advanced gastric cancer.Yang L, Jiang X, Yan H, Li Y, Zhen H, Chang B, Kariminia S, Li Q. BMC Gastroenterol. 2018 Apr 2; 18(1):43. Epub 2018 Apr 2.
- Review [Irinotecan (CPT-11) therapy for advanced gastric cancer].[Nihon Rinsho. 2001]Review [Irinotecan (CPT-11) therapy for advanced gastric cancer].Sakata Y. Nihon Rinsho. 2001 Apr; 59 Suppl 4:386-92.
- Chemotherapy with or without irinotecan in patients with advanced or recurrent g...Chemotherapy with or without irinotecan in patients with advanced or recurrent gastric cancer: a meta-analysis of randomized controlled trials - Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews
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