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Benzodiazepines in Older Adults: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines [Internet]

Benzodiazepines in Older Adults: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines [Internet]

Rapid Response Report: Peer-Reviewed Summary with Critical Appraisal - Canadian Agency for Drugs and Technologies in Health

Version: January 2011

SUMMARY OF FINDINGS

No studies directly addressed any of the research questions on the safety, comparative efficacy, and cost-effectiveness of using benzodiazepines in older adults to manage disruptive behaviour or treat anxiety. The literature search identified a total of 596 citations, and 15 publications were included in this report (Appendix 3). Six relevant systematic reviews addressed the association between benzodiazepine use in older adults and falls,, cognitive decline, fractures, cognitive and psychomotor adverse events, and mortality. Nine evidence-based guidelines and recommendations addressed the use of benzodiazepines by older adults for dementia,– mood and behavioural disorders, panic disorder, and sleep disorders.–

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