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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

Association between lumican gene -1554 T/C polymorphism and high myopia in Asian population: a meta-analysis

Review published: 2013.

Bibliographic details: Liao X, Yang XB, Liao M, Lan CJ, Liu LQ.  Association between lumican gene -1554 T/C polymorphism and high myopia in Asian population: a meta-analysis. International Journal of Ophthalmology 2013; 6(5): 696-701. [PMC free article: PMC3808924] [PubMed: 24195052]

Abstract

AIM: To investigate the association between lumican gene -1554 T/C polymorphism and high myopia susceptibility.

METHODS: We searched the published literature in the Medline, Embase, and CBM databases from inception to July 2013. A meta-analysis was performed by the programs RevMan 5.1 and Stata 12.0, and the odds ratio (OR) with 95% confidence interval (CI) was calculated in fixed or random effect model based on heterogeneity test among studies.

RESLUTS: Seven case-control studies with a total of 1 233 cases and 936 controls were included. A statistical significant association with high myopia was observed in the recessive model (TT vs CT+CC: OR=1.92; 95%CI=1.14-3.23) and codominant model (TT vs CT: OR=1.81, 95%CI=1.19-2.75).

CONCLUSION: The present meta-analysis suggested that lumican -1554 T/C polymorphism might be moderately associated with high myopia susceptibility. This conclusion warrants confirmation by further studies.

CRD has determined that this article meets the DARE scientific quality criteria for a systematic review.

Copyright © 2014 University of York.

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