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Atypical Antipsychotics for Schizophrenia: Combination Therapy and High Doses [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2011 Dec. (CADTH Optimal Use Report, No. 1.1.)

APPENDIX 11DEFINITION OF RESPONSE TO ANTIPSYCHOTIC DRUG TREATMENT REPORTED IN INCLUDED RCTS

Author (Year)Definition of Response
AKDEDE et al. (2005)4220% improvement in PANSS-T
ANIL YAGCIOGLU et al. (2005)4520% improvement in PANSS-T
ASSION et al. (2008)49NR
AZORIN et al. (2001)6020% BPRS reduction plus CGI score ≤ 3 or end point CGI ≤ 3.5
BONDOLFI et al. (1998)66PANSS total score reduced by 20% or more from baseline
CHANG et al. (2008)38NR
CITROME et al. (2001)59NR
CLAUS et al. (1992)68PANSS total score reduced by 20% or more from baseline
CONLEY et al. (1988)6520% improvement in BPRS total score
CONLEY et al. (2003)7620% drop in BPRS score
CZOBOR et al. (2002)71NR
FLEISCHHACKER et al. (2010)54An improvement of ≥ 30% from baseline in PANSS total score
FREUDENREICH et al. (2007)41PANSS total improves by ≥ 20%
GENC et al. (2007)50NR
GREEN at al. (1997)67NR
HONER et al. (2006)44Treatment response was defined as those with a decrease in total PANSS score of at least 20%
HONER et al. (2011)7220% or greater improvement in total PANSS score
JOSIASSEN et al. (2005)4620% reduction in BPRS total score at the end
KANE et al. (2009)36≥ 20% decrease from baseline in PANSS-T or CGI-I score of 1 or 2
KELLY et al. (2003)48NR
KELLY et al. (2006)43NR
KERN et al. (1998)64NR
KERN et al. (1999)62NR
KOTLER et al. (2004)47NR
KUMRA et al. (2008)40To reflect a clinically meaningful improvement the primary protocol efficacy measure as categorical response, which was defined as a decrease of 30% or more in total BPRS score from the baseline to endpoint and a Clinical Global Impression Scale improvement rating of “1” (very much improved) or “2” (much improved).
KUWILSKY et al. (2010)55see ZINK et al. (2009)37
LINDENMAYER et al. (2003)57NR
McEVOY et al. (2006)70NR
MELTZER et al. (2008)39≥ 20% decrease from baseline in PANSS-T at 6 months for completers and at 6 wks for those who dropped out after wk 6 for reasons other than lack of efficacy
MILLAR et al. (2008)74NR
MOSSAHEB et al. (2006)73NR
RICHARDSON et al. (2009)75NR
ROSENHECK et al. (1999)6320% improvement on either PANSS or the Heinrichs-Carpenter Quality of Life Scale
SHAFTI, (2009)52NR
SHILOH et al. (1997)51A reduction of more than 20% in the BPRS scores
TOLLEFSON et al. (2001)53Achieved ≥20% reduction in BPRS, total score from baseline to endpoint, plus either an endpoint CGI-S score of ≤ 3 or an endpoint BPRS total score of ≤ 3.5
VOLAVKA et al. (2002)58NR
VOLAVKA et al. (2004)56NR
WEINER et al. (2010)69NR
WIRSHING et al. (1999)6120% or more improvement in BPRS scores at the end of the flexible phase and CGI at most less than 3 mild or a total score of 3.5 or less on the 18-items BPRS
ZINK et al. (2009)37Reduction of the PANSS by 20% or reduction of PANSS-positive by 20%
Copyright © 2011 Canadian Agency for Drugs and Technologies in Health.
Cover of Atypical Antipsychotics for Schizophrenia: Combination Therapy and High Doses
Atypical Antipsychotics for Schizophrenia: Combination Therapy and High Doses [Internet].
CADTH Optimal Use Report, No. 1.1.

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