Home > Full Text Reviews > New Oral Anticoagulants for the... > Random-Effects Frequentist GLMM Network...

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.

New Oral Anticoagulants for the Prevention of Thromboembolic Events in Patients with Atrial Fibrillation [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2012.

7.13Random-Effects Frequentist GLMM Network Meta-analysis

George Wells, PhD, Doug Coyle, PhD, Chris Cameron, MSc PhD (candidate), Sabine Steiner, MD MSc, Kathryn Coyle, BScPharm MSc, Shannon Kelly, MSc (candidate), Anthony Tang, MD FRCPC, Jeff Healey, MD FRCPC, Shu-Ching Hsieh, PhD, and Judith van Berkom, BA.

Author Information

George Wells, PhD,1 Doug Coyle, PhD,2 Chris Cameron, MSc PhD (candidate),1 Sabine Steiner, MD MSc,3 Kathryn Coyle, BScPharm MSc,4 Shannon Kelly, MSc (candidate),1 Anthony Tang, MD FRCPC,5 Jeff Healey, MD FRCPC,6 Shu-Ching Hsieh, PhD,1 and Judith van Berkom, BA7.

1 University of Ottawa Heart Institute, Ottawa, Ontario
2 University of Ottawa, Ottawa, Ontario
3 Medical University of Vienna, Vienna, Austria
4 Coyle Consultancy, Ottawa, Ontario
5 University of British Columbia, Victoria, British Columbia
6 McMaster University, Hamilton, Ontario
7 Independent contractor: Information Specialist, Ottawa, Ontario

Table 66Summary of Results from Random-Effects Frequentist GLMM Network Meta-analysis Versus Adjusted-Dose Warfarin — OR (95% CI) for Each Outcome

Stroke/SEMajor
Bleeding
All-cause
Mortality
Intracranial
Bleeding
Major GI
Bleeding
Myocardial
Infarction
Apixaban 5 mg b.i.d.0.76 (0.52 to 1.10)0.69 (0.50 to 0.94)0.89 (0.69 to 1.15)0.43 (0.22 to 0.82)0.85 (0.48 to 1.49)0.85 (0.46 to 1.56)
Dabigatran 110 mg b.i.d.0.93 (0.62 to 1.39)0.82 (0.59 to 1.12)0.91 (0.68 to 1.22)0.33 (0.14 to 0.79)1.11 (0.65 to 1.88)1.29 (0.68 to 2.43)
Dabigatran 150 mg b.i.d.0.66 (0.42 to 1.04)0.95 (0.70 to 1.29)0.89 (0.66 to 1.19)0.46 (0.22 to 0.98)1.52 (0.93 to 2.48)1.26 (0.67 to 2.39)
Rivaroxaban 20 mg q.d.0.81 (0.54 to 1.20)1.02 (0.75 to 1.39)0.82 (0.55 to 1.24)0.59 (0.31 to 1.12)1.50 (0.95 to 2.35)0.83 (0.47 to 1.47)

b.i.d. = twice daily; CI = confidence interval; GI = gastrointestinal; GLMM = generalized linear mixed models; q.d. = once daily.

Authorship

George Wells wrote the protocol for this review and acted as the primary lead in the conception, design and implementation of the project, as well as all aspects of the development and writing of the report and responses to internal and external reviewers.

Doug Coyle planned and led the economic section, selected articles, and extracted data for the economic review; performed the primary economic analyses; wrote the economic sections; and contributed to revisions and responses to internal and external reviewers.

Chris Cameron extracted and checked data; performed Bayesian mixed treatment comparisons metaanalyses; wrote sections and prepared tables and figures for the clinical review; and contributed to revisions and responses to internal and external reviewers.

Sabine Steiner extracted and checked data; performed frequentist mixed treatment comparisons metaanalyses, wrote sections of the clinical review, and contributed to revisions and responses to internal and external reviewers.

Kathryn Coyle assisted with the development of the methods for the economic analysis; selected economic studies; extracted, tabulated, and analyzed data; and contributed to writing the economic sections of the report.

Shannon Kelly contributed to writing the protocol; led and participated in article selection, study quality assessment, data extraction and tabulation, subgroup appraisal and preparation of tables for the clinical review; wrote and edited sections of the clinical review; contributed to revisions and responses to internal and external reviewers; and edited the final draft.

Anthony Tang provided clinical guidance and feedback for this review; co-wrote the Introduction and Background section in the protocol and this review; assisted with the writing of the Discussion section; and contributed to revisions and responses to external reviewers.

Jeff Healey provided clinical guidance and feedback for this review; co-wrote the Introduction and Background section in the protocol and this review; assisted with the writing of the Discussion section; and contributed to revisions and responses to external reviewers.

Shu-Ching Hseih participated in article selection, study quality assessment, data extraction and checking, subgroup appraisal and preparation of tables for the clinical review; assisted with referencing of studies in the final draft; and contributed to revisions.

Judith van Berkom developed the literature search strategies and performed all searches, managed report referencing, and composed the search methodology sections.

Copyright © 2012 CADTH.
Cover of New Oral Anticoagulants for the Prevention of Thromboembolic Events in Patients with Atrial Fibrillation
New Oral Anticoagulants for the Prevention of Thromboembolic Events in Patients with Atrial Fibrillation [Internet].

PubMed Health Blog...

read all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...