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Appendix F Table 4Cardiovascular Disease and Cancer Incidence, Mortality, and All-Cause Mortality Among Vitamin D Alone vs. Placebo Arms of the RECORD Trial103

OutcomeMean followup (y)Intervention, # of subjects (%)Comparator, # of subjects (%)RR95% CIP-value
Any CVD death6.2173/1,343 (12.9)182/1,332 (13.7)NRNRNR
Fatal CHD6.274/1,343 (5.5)85/1,332 (6.4)NRNRNR
Fatal stroke6.259/1,343 (4.4)51/1,332 (3.8)NRNRNR
Any cancer6.2187/1,343 (13.9)165/1,332 (12.4)NRNRNR
Breast cancer6.223/1,343 (1.7)16/1,332 (1.2)NRNRNR
Colorectal cancer6.217/1,343 (1.3)8/1,332 (0.6)NRNRNR
Lung cancer6.214/1,343 (1.0)18/1,332 (1.4)NRNRNR
Prostate cancer6.29/1,343 (0.7)8/1,332 (0.6)NRNRNR
Any cancer death6.273/1,343 (5.4)78/1,332 (5.9)NRNRNR
Breast cancer death6.27/1,343 (0.5)4/1,332 (0.3)NRNRNR
Colorectal cancer death6.27/1,343 (0.5)6/1,332 (0.5)NRNRNR
Lung cancer death6.210/1,343 (0.7)21/1,332 (1.6)NRNRNR
All-cause mortality6.2421/1,343 (31.3)434/1,332 (32.6)NRNRNR

Abbreviations: CHD = coronary heart disease; CI = confidence interval; CVD = cardiovascular disease; NR = not reported; RECORD = Randomized Evaluation of Calcium or Vitamin D; RR = relative risk; y = years.

From: Appendix F, Outcomes Reported by Original Randomized Arms Among the 2×2 Factorial-Designed Randomized, Controlled Trials

Cover of Vitamin, Mineral, and Multivitamin Supplements for the Primary Prevention of Cardiovascular Disease and Cancer
Vitamin, Mineral, and Multivitamin Supplements for the Primary Prevention of Cardiovascular Disease and Cancer: A Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet].
Evidence Syntheses, No. 108.
Fortmann SP, Burda BU, Senger CA, et al.

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