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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews.

Polymorphisms in the tumor necrosis factor gene and susceptibility to Behcet's disease: an updated meta-analysis

Review published: 2013.

Bibliographic details: Zhang M, Xu WD, Wen PF, Liang Y, Liu J, Pan HF, Ye DQ.  Polymorphisms in the tumor necrosis factor gene and susceptibility to Behcet's disease: an updated meta-analysis. Molecular Vision 2013; 19: 1913-1924. [PMC free article: PMC3774576] [PubMed: 24049437]

Abstract

PROPOSE: Studies investigating the association between the tumor necrosis factor (TNF) gene polymorphisms and Behcet's disease (BD) report conflicting results. The aim of this meta-analysis was to assess the association between TNF gene polymorphisms and BD.

METHODS: A systematic literature search was conducted to identify all relevant studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of the association.

RESULTS: A total of 16 articles, involving 1,708 patients with BD and 1,910 healthy controls, were included in the meta-analysis. Overall, a significant association was found between BD and the TNF -308A/G polymorphism (OR=0.730, 95% CI=0.608-0.877, p=0.001). Meta-analysis of TNF -238A/G showed significant association with BD (OR=1.512, 95% CI=1.155-1.979, p=0.003). The TNF -1031C allele showed significant association with BD (OR=1.549, 95% CI=1.190-2.015, p=0.001). Similarly, the meta-analysis showed a significant association of the TNF -857T/C polymorphism with BD (OR=0.758, 95% CI=0.593-0.968, p=0.027). Stratification by ethnicity revealed that the -308A/G and -857T/C polymorphisms were associated with BD in the Asian group, while the -238A/G and -1031C/T polymorphisms were associated with BD in the Caucasian population.

CONCLUSIONS: The results of our meta-analysis suggest that TNF (-308A/G, -238A/G, -1031C/T, and -857T/C) polymorphisms are associated with susceptibility to BD.

CRD has determined that this article meets the DARE scientific quality criteria for a systematic review.

Copyright © 2013 University of York.

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