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Table 36Study characteristics and association between OC use and endometrial cancer incidence

StudyaStudy DetailsORb95% CICovariatesRegionStudy QualityMeta-Analysis Codec
Case-Control
Parslov, 2000250Danish women aged 25–49 yr
Cases: 237 endometrial cancer, hospital
Controls: 538, Central Person Register

Recruitment period: 1987–1994
NRNRNADenmarkGood2
Maxwell, 2006251Women aged 20–54 yr in Cancer and Steroid Hormone Study
Cases: 434 endometrial cancer, SEER registry
Controls: 2557, population
0.210.10 to 0.43NAU.S.Good1
High progestin/high estrogen0.000.00 to 5.59
High progestin/low estrogen0.390.25 to 0.60
Low progestin/high estrogen0.400.21 to 0.76
Low progestin/Low estrogen
Recruitment period: 1980–1982
Tao, 2006254Women aged 30–69 yr in Shanghai Endometrial Cancer Study
Cases: 1204 endometrial cancer, registry
Controls: 1212 no history of hysterectomy, resident registry

Recruitment period: 1997–2003
0.750.60 to 0.93Age, parity, menopausal status, BMI, family history, age at menarche, education, yr of menstruation, family history of breast, endometrial, and colon cancers, age at last live birth, physical activity, exogenous hormone useChinaGood1
Urban, 2012155Black South African women aged 18–79 yr
Cases: 17, hospital
Controls: 156, hospital

Recruitment period: 1995–2006
1.010.55 to 1.85Age, parity, smoking, year of diagnosis, education, alcohol consumption, sexual partners, urban/rural residence, province of birthSouth AfricaGood1
Cohort
Vessey, 2006156Women aged 25–39 yr in Oxford Family Planning Association Contraceptive Study
Exposed: 301,000 person-years
Unexposed: 187,000 person-years

Recruitment period: 1968–1974
0.30.2 to 0.6Age, parity, BMI, smoking, social class, height, age at first term pregnancy, age at first marriageUKGood1
Hannaford, 200737Royal College of General Practitioner's Oral Contraception Study
Exposed: 744,000 person-years
Unexposed: 339,000 person-years

Mean age at study entry: 29 (SD 6.6)
Recruitment period: 1968–NR
0.580.42 to 0.79Age, parity, smoking, social statusUKFair1
Setiawan, 2007253Women aged 45–75 yr in Multiethnic Cohort Study Hawaii and Los Angeles
46,933 (total population of exposed and unexposed, postmenopausal women)

Recruitment period: 1993–1996
NRNRNAU.S.Good2
Rosenblatt, 2009138Textile workers in Shanghai aged 30–64 yr
Exposed: 352,695 person-years
Unexposed: 2,057,377 person-years

Recruitment period: 1989–1991
0.680.45 to 1.04Age, parity, tubal ligationChinaPoor1
Dossus, 2010252European Prospective Investigation into Cancer and Nutrition
Exposed: 1017
Unexposed: 301,601

1017 Cases, 301601 Cases

Mean age of cases at entry: 56.2
Recruitment period: 1992–NR
0.650.56 to 0.75BMI, smoking, physical activity, alcohol, diabetes, education10 European countriesFair1

BMI = body mass index; CI = confidence interval; NA = not applicable; NR = not reported; OC = oral contraceptive; OR = odds ratio; UK = United Kingdom; U.S. = United States; yr = year/years

a

Study identifies the primary abstracted article. For details about the relationships between companion studies and articles, refer to Tables C-1 and C-2 in Appendix C.

b

Odds ratio for meta-analysis of ever versus never OC use.

c

Meta-analysis code: 1 = Included in this meta-analysis; 2 = Excluded due to ever versus never OR not reported.

Study identifies the primary abstracted article. For details about the relationships between companion studies and articles, refer to Tables C-1 and C-2 in Appendix C.

Odds ratio for meta-analysis of ever versus never OC use.

Meta-analysis code: 1 = Included in this meta-analysis; 2 = Excluded due to ever versus never OR not reported.

From: 3, Oral Contraceptives and Other Cancers

Cover of Oral Contraceptive Use for the Primary Prevention of Ovarian Cancer
Oral Contraceptive Use for the Primary Prevention of Ovarian Cancer.
Evidence Reports/Technology Assessments, No. 212.
Havrilesky LJ, Gierisch JM, Moorman PG, et al.

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