This figure depicts key question 3 within the context of the PICOTS described in a later section. The figure illustrates how local curative or palliative therapies for unresectable, advanced stage (IIIa, IIIb, and IV) non-small cell lung cancer may improve overall survival, cancer-specific survival, pulmonary quality-of-life, and performance status in patients with pulmonary signs and symptoms of obstruction, and affect intermediate outcomes such as local control, recurrence, lung function (eg,FEV1), dyspnea, bleeding, and infections. Important adverse effects include RT-associated AEs (eg, pneumonitis, cardiotoxicity, hemoptysis, dermatitis, etc), pneumothorax, pleural effusion, and procedural mortality.

Figure BAnalytical framework for comparative effectiveness of local nonsurgical curative or palliative therapies for adult patients (age 18 years or older) with symptomatic inoperable airway obstruction due to NSCLC

2DRT = two-dimensional radiotherapy; 3DRT = three-dimensional radiotherapy; AE = adverse event; IMRT = intensity-modulated radiotherapy; KQ = Key Question; NSCLC = non–small cell lung cancer; RFA = radiofrequency ablation; SBRT = stereotactic body radiotherapy

From: Executive Summary

Cover of Local Nonsurgical Therapies for Stage I and Symptomatic Obstructive Non–Small-Cell Lung Cancer
Local Nonsurgical Therapies for Stage I and Symptomatic Obstructive Non–Small-Cell Lung Cancer [Internet].
Comparative Effectiveness Reviews, No. 112.
Ratko TA, Vats V, Brock J, et al.

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