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Migraine in Children: Preventive Pharmacologic Treatments [Internet]

Migraine in Children: Preventive Pharmacologic Treatments [Internet]

Comparative Effectiveness Reviews - Agency for Healthcare Research and Quality (US)

Version: June 2013

Results

Of 510 retrieved references, we excluded 104 at screening as not relevant to pediatric migraine, and we reviewed full texts of 312 references (Figure 2). We ultimately included 24 references of randomized controlled clinical trials, two abstracts of randomized controlled clinical trials, and 16 nonrandomized studies. We did not rank strength of evidence for two RCTs of flunarizine because, despite being commonly used elsewhere, this drug is not approved by the FDA. We found one eligible FDA review that evaluated a clinical trial of divalproex sodium used to prevent migraine headache in adolescents.

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