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Executive Summary Table 1KQ1 – Cancer: Strength of Evidence for Trials Comparing Therapy with Family Component to Usual Care or Wait List Control

Outcome# studies
(n*)
# studies of each intervention category
Risk of biasDirectnessPrecisionConsistencyEvidence rating
Physical functioning9
(1266)
Phone=3;CBT=2;FAA=1;FFSM=2;Misc=1
Moderate: all trials rated fair qualityDirectImprecise. One trial reported a statistically significant difference versus usual care. Non-significant effect sizes ranged from small to large with wide confidence intervals (seven trials). One trial reported a non-significant difference (point estimate could not be calculated).ConsistentLow
General psychological functioning10
(1410)
Phone=3;CBT=4;FAA=1;FFSM=1;Misc=1
Moderate: nine trials rated fair quality; one rated poorDirectImprecise. Two trials reported statistically significant differences versus usual care. Non-significant effect sizes were small with wide confidence intervals (seven trials). One trial reported a non-significant difference (point estimate could not be calculated).ConsistentLow
Social functioning5
(749)
Phone=1;CBT=0; FAA=1;FFSM=2;Misc=1
Moderate: all trials rated fair qualityDirectImprecise. One trial reported a statistically significant difference versus usual care. Non-significant effect sizes were small with wide confidence intervals (three trials). One trial reported a non-significant difference (point estimate could not be calculated).ConsistentLow
Global quality of life6
(1367)
Phone=1;PAA=1; FAA=1; FFSM=3; Misc=0
Moderate: five trials rated fair quality; one rated poorDirectImprecise. No trial reported a statistically significant difference versus usual care. Non-significant effect sizes ranged were small with wide confidence intervals (four trials). One trial reported a non-significant difference (point estimate could not be calculated). Significance could not be determined for another trial.ConsistentLow
Depression/anxiety9
(1519)
Phone=2;CBT=1;FAA=3;FFSM=2;Misc=1
Moderate: six trials rated fair quality; three rated poorDirectImprecise. Two trials reported statistically significant differences versus usual care. Non-significant effect sizes were small with wide confidence intervals (seven trials).ConsistentLow
Symptom control/management11**
(1673)
Phone=3;CBT=2;FAA=3;FFSM=2;Misc=1
Moderate: nine trials rated fair quality; two rated poorDirectImprecise. Four trials reported statistically significant differences versus usual care. One trial reported intervention was “superior” with medium to large effect sizes. Non-significant effect sizes were small (five trials). Significance could not be determined in one trial.ConsistentLow
*

Number of subjects randomized

**

Some studies had multiple outcome measures

Intervention Category: Phone=Telephone or Web-based; CBT=Couples cognitive behavior therapy; FAA=Family assisted approaches to patient care; FFSM=Family focused CBT with coping and problem solving; Misc=Unique intervention

Number of subjects randomized

Some studies had multiple outcome measures

From: EXECUTIVE SUMMARY

Cover of Effectiveness of Family and Caregiver Interventions on Patient Outcomes Among Adults with Cancer or Memory-Related Disorders: A Systematic Review
Effectiveness of Family and Caregiver Interventions on Patient Outcomes Among Adults with Cancer or Memory-Related Disorders: A Systematic Review [Internet].
Griffin JM, Meis L, Greer N, et al.
Washington (DC): Department of Veterans Affairs; 2013 Apr.

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