• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Table 23KQ2 – Memory-Related Disorders: Strength of Evidence for Trials Comparing Therapy with Family Component to Alternative Interventions

Outcome# studies
(n*)
# studies of each intervention category
Risk of biasDirectnessPrecisionConsistencyEvidence rating
Physical functioning5**
(852)
FAA=3;FFSM=2
Moderate: one trial rated good quality; two fair, two poorDirectImprecise. One trial reported statistically significant difference versus alternative interventions. Two trials reported non-significant differences (small effect sizes or effect sizes not reported). Significance not reported or could not be determined in two trials.UnknownLow
Cognitive functioning6**
(675)
FAA=1;FFSM=3; Misc=2
Moderate: one trial rated good quality; two fair; three poorDirectImprecise. No trial reported a statistically significant difference versus alternative interventions. Effect sizes were small to medium with wide confidence intervals.ConsistentLow
Quality of life2**
(755)
FFSM=2
Moderate: one trial rated good quality; one fairDirectImprecise. One trial reported a statistically significant difference versus attention control. One trial reported a small, non-significant effect.UnknownLow
Symptom control/management12**
(1820)
FAA=5;FFSM=4; Misc=3
Moderate: three trials rated good quality; four fair; five poorDirectImprecise. Three trials reported statistically significant differences versus alternative interventions. Non-significant effect sizes were small with wide confidence intervals (five trials). Two trials reported non-significant differences (effect sizes could not be calculated). Significance not reported or could not be determined in two trials.ConsistentLow
Depression/anxiety2**
(108)
FFSM=1; Misc=1
Moderate: one trial rated good quality; one fairDirectImprecise. One trial reported a significant difference in change from baseline on one depression outcome compared to attention control. Another depression outcome did not differ significantly between groups. The second trial reported non-significant differences with small effect sizes.ConsistentLow
*

Number of subjects randomized

**

Some studies had multiple outcomes measures

Intervention Category: Phone=Telephone or Web-based; CBT=Couples cognitive behavior therapy; FAA=Family assisted approaches to patient care; FFSM=Family focused CBT with coping and problem solving; Misc=Unique intervention

Number of subjects randomized

Some studies had multiple outcomes measures

From: RESULTS

Cover of Effectiveness of Family and Caregiver Interventions on Patient Outcomes Among Adults with Cancer or Memory-Related Disorders: A Systematic Review
Effectiveness of Family and Caregiver Interventions on Patient Outcomes Among Adults with Cancer or Memory-Related Disorders: A Systematic Review [Internet].
Griffin JM, Meis L, Greer N, et al.
Washington (DC): Department of Veterans Affairs; 2013 Apr.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.