Table 11Summary of ablative therapy study characteristics: RCTs

Study
N
Rating
InterventionIntervention PeriodMean Age
(Range)
CP
A%; B%
BCLC
A%; B%
Previous LDT %
Brunello et al. 200850
139
Good
RFA under US guidance with either cool tip or multitined electrodes for 12 min or 15–25 min, respectively01/2001 - 09/200469.0
(NR)
A: 55.7;
B: 44.3
NRNR
PEI with sterile ethanol (95%, 2–20 mL) injected into each lesion with a single needle (1–4 sessions)01/2001 - 09/200470.3
(NR)
A: 56.5;
B: 43.5
NRNR
Lin et al. 200451
157
Fair
Percutaneous RFA with 15-gauge electrode under US guidance repeated 2 weeks later for up to 2 courses per tumor04/2000 - 04/200262
(NR)
A: 79;
B: 21
NRNR
PEI with 99.5% ethanol (volume per session mean: 4.5 mL, SD: 1.6 mL, range: 2–10 mL) using a single transhepatic cholangiography needle twice weekly for up to 6 sessions per tumor per course and 12 sessions of the maximal treatment per tumor04/2000 - 04/200259
(NR)
A: 75;
B: 25
NRNR
PEI with 99.5% ethanol (volume per session mean: 8.5 mL, SD: 2.8 mL, range: 6–18 mL) using two transhepatic cholangiography needles and a third needle if needed twice weekly for up to 3 sessions per tumor per course and 6 sessions of the maximal treatment per tumor04/2000 - 04/200261
(NR)
A: 74;
B: 26
NRNR
Lin et al. 200552
187
Fair
Percutaneous RFA with 15-gauge electrode under US guidance repeated 2 weeks later for up to 2 courses per tumor04/2000 - 06/200261
(NR)
A: 74.2;
B: 25.8
NRNR
PEI with 99.5% ethanol (volume per session mean: 4.8 mL, SD: 1.4 mL, range: 2–10.4 mL) twice weekly for up to 6 sessions per tumor per course and 12 sessions of the maximal treatment per tumor04/2000 - 06/200260
(NR)
A: 75.8;
B: 24.2
NRNR
PAI with 50% acetic acid (volume per session mean: 2.2 mL, SD: 1.1 mL, range: 1–3.5 mL) twice weekly for up to 6 sessions per tumor per course and 12 sessions of the maximal treatment per tumor04/2000 - 06/200263
(NR)
A: 71.4;
B: 28.6
NRNR

Abbreviations: BCLC = Barcelona Clinic Liver Center hepatocellular carcinoma stage; CP = Child-Pugh liver cirrhosis class; LDT = liver-directed therapy; N = number of patients; NR = not reported; PAI = percutaneous acetic acid injection; PEI = percutaneous ethanol injection; RFA = radiofrequency ablation; SD = standard deviation; US = ultrasound.

From: Results

Cover of Local Therapies for Unresectable Primary Hepatocellular Carcinoma
Local Therapies for Unresectable Primary Hepatocellular Carcinoma [Internet].
Comparative Effectiveness Reviews, No. 114.
Belinson S, Yang Y, Chopra R, et al.

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