Figure 3 is a flow chart that summarizes the search and selection of articles. Our search identified 7746 citations by searching Pubmed, Embase, Cochrane and Lilacs (after removing duplicates). During the abstract review process, we excluded 5942 citations which did not meet eligibility criteria. At the level of full-text article review, we excluded another 1626 and included 178 articles for data abstraction. At this level we excluded 36 articles and included 142 articles for the final analysis. All of the included studies were RCTs. We included 74 references in the final report that investigated the efficacy and safety of subcutaneous immunotherapy, 60 studies that investigated the efficacy and safety of sublingual immunotherapy, and 8 studies that compared subcutaneous immunotherapy and sublingual immunotherapy

Figure 3Literature search

RCT = randomized controlled trial; SCIT = subcutaneous immunotherapy; SLIT = sublingual immunotherapy

* Total may exceed number in corresponding box, as articles were excluded by two reviewers at this level.

** Other reasons: Control group is healthy population, routes of administration not included, abandoned interventions, outcomes not reported, no comparator group, continued medical education reports, editorials or reviews, studies about mechanism or action, other allergies (food, aspirin).

From: Results

Cover of Allergen-Specific Immunotherapy for the Treatment of Allergic Rhinoconjunctivitis and/or Asthma: Comparative Effectiveness Review
Allergen-Specific Immunotherapy for the Treatment of Allergic Rhinoconjunctivitis and/or Asthma: Comparative Effectiveness Review [Internet].
Comparative Effectiveness Reviews, No. 111.
Lin SY, Erekosima N, Suarez-Cuervo C, et al.

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