Minimal important difference (MID)

The MID is the smallest difference in score in the outcome of interest that informed patients or informed proxies perceive as important, either beneficial or harmful, and that would lead the patient or clinician to consider a change in the management (insert refs). This term was adapted from the earlier definition used for MCID (minimal clinically important difference) with the term “clinical” removed to emphasise on the importance of patient perspective. The term “MID” has been adopted by GRADE. In this guidance, we also use the term to refer to the clinically important thresholds or harms when considering imprecision.