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Table 74Intensive investigations for cancer – Clinical summary of findings

OutcomeIntensive investigationsRoutine investigationsEffect measureAbsolute effectQuality
Cancer related mortality at 2 years2/99 (2%)4/102(3.9%)RR 0.52 (0.10 to 2.75)19 fewer per 1000 (from 35 fewer to 69 more)LOW
Early stage cancer detection (T1 and T2)9/14 (64%)2/10 (20%))3.21 [0.88, 11.79]442 more per 1000 (from 24 fewer to 1000 more)LOW
Delay in cancer diagnosis (months)1.0 (in 14 patients)11.6 ( in 10 patients)Not applicable10.6 months longer for routine investigations, p<0.001 reported in papersLOW
Sensitivity of the intensive cancer investigation strategy13/14 detected out of 99 patientsNot applicabl eSensitivity; 92.85%, (CI 66–100%)72 cases missed per 1000 cancer patients (from 440 missed to none missed)LOW

From: 13, Investigations for cancer in VTE patients

Cover of Venous Thromboembolic Diseases
Venous Thromboembolic Diseases: The Management of Venous Thromboembolic Diseases and the Role of Thrombophilia Testing [Internet].
NICE Clinical Guidelines, No. 144.
National Clinical Guideline Centre (UK).
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