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Study identification (include author, title, reference, year of publication)
Guideline topic:Review question no:
Checklist completed by:
Circle one option for each question
A. Selection bias (systematic differences between the comparison groups)
A1An appropriate method of randomisation was used to allocate participants to treatment groups (which would have balanced any confounding factors equally across groups)YesNoUnclearN/A
A2There was adequate concealment of allocation (such that investigators, clinicians and participants cannot influence enrolment or treatment allocation)YesNoUnclearN/A
A3The groups were comparable at baseline, including all major confounding and prognostic factorsYesNoUnclearN/A
Based on your answers to the above, in your opinion was selection bias present? If so, what is the likely direction of its effect?
Low risk of biasUnclear/unknown riskHigh risk of bias
Likely direction of effect:
B. Performance bias (systematic differences between groups in the care provided, apart from the intervention under investigation)
B1The comparison groups received the same care apart from the intervention(s) studiedYesNoUnclearN/A
B2Participants receiving care were kept ‘blind’ to treatment allocationYesNoUnclearN/A
B3Individuals administering care were kept ‘blind’ to treatment allocationYesNoUnclearN/A
Based on your answers to the above, in your opinion was performance bias present? If so, what is the likely direction of its effect?
Low risk of biasUnclear/unknown riskHigh risk of bias
Likely direction of effect:
C. Attrition bias (systematic differences between the comparison groups with respect to loss of participants)
C1All groups were followed up for an equal length of time (or analysis was adjusted to allow for differences in length of follow-up)YesNoUnclearN/A
C2a. How many participants did not complete treatment in each group?
b. The groups were comparable for treatment completion (that is, there were no important or systematic differences between groups in terms of those who did not complete treatment)YesNoUnclearN/A
C3a. For how many participants in each group were no outcome data available?
b. The groups were comparable with respect to the availability of outcome data (that is, there were no important or systematic differences between groups in terms of those for whom outcome data were not available).YesNoUnclearN/A
Based on your answers to the above, in your opinion was attrition bias present? If so, what is the likely direction of its effect?
Low risk of biasUnclear/unknown riskHigh risk of bias
Likely direction of effect:
D. Detection bias (bias in how outcomes are ascertained, diagnosed or verified)
D1The study had an appropriate length of follow-upYesNoUnclearN/A
D2The study used a precise definition of outcomeYesNoUnclearN/A
D3A valid and reliable method was used to determine the outcomeYesNoUnclearN/A
D4Investigators were kept ‘blind’ to participants' exposure to the interventionYesNoUnclearN/A
D5Investigators were kept ‘blind’ to other important confounding and prognostic factorsYesNoUnclearN/A
Based on your answers to the above, in your opinion was detection bias present? If so, what is the likely direction of its effect?
Low risk of biasUnclear/unknown riskHigh risk of bias
Likely direction of effect:

From: Appendix 11, Quality checklist templates for clinical studies and reviews

Cover of Self-Harm: Longer-Term Management
Self-Harm: Longer-Term Management.
NICE Clinical Guidelines, No. 133.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2012.
Copyright © 2012, The British Psychological Society & The Royal College of Psychiatrists.

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