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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews.

Indirect meta-analysis of randomised placebo-controlled clinical trials on rasagiline and selegiline in the symptomatic treatment of Parkinson's disease

Review published: 2012.

Bibliographic details: Jost WH, Friede M, Schnitker J.  Indirect meta-analysis of randomised placebo-controlled clinical trials on rasagiline and selegiline in the symptomatic treatment of Parkinson's disease. Basal Ganglia 2012; 2(4 Supplement): S17-S26.

Quality assessment

This review concluded that there were statistically and clinically significant benefits to rasagiline over selegiline for the treatment of Parkinson's disease, in terms of both efficacy and safety. There are concerns over the synthesis methods and the relatively small size and number of trials. The conclusions appear overly strong and may not be reliable. Full critical summary

CRD has determined that this article meets the DARE scientific quality criteria for a systematic review.

Copyright © 2013 University of York.

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