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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews.

Lack of association between TNF-alpha promoter polymorphisms and multiple myeloma: a meta-analysis

Review published: 2013.

Bibliographic details: Li B, Wang XD, Sun X, Ma J, Yang Y, Ma X.  Lack of association between TNF-alpha promoter polymorphisms and multiple myeloma: a meta-analysis. Leukemia Research 2013; 37(1): 50-57. [PubMed: 22999526]

Abstract

Results of available literatures, which concerned the association between TNF-α promoter -238/-308 gene polymorphisms and multiple myeloma (MM), are of great controversy. A review was performed in studies reporting on the association between them. Odds ratios (ORs) with 95% confidence interval (CI) were used to evaluate the association. The pooled ORs indicated that there was no association between TNF-α -238/-308 polymorphisms and MM susceptibility in overall population. Sub-group analysis also confirmed that no evidence supported the relevance of TNF-α promoter -238/-308 gene polymorphisms with MM. Studies with large sample size and multi-ethnics may be needed to further explore the association between them.

Copyright © 2012 Elsevier Ltd. All rights reserved.

CRD has determined that this article meets the DARE scientific quality criteria for a systematic review.

Copyright © 2014 University of York.

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