Table 8.19Evidence profile for continuous pump-administered intrathecal baclofen compared with usual care; adverse events and complications

Number of studiesNumber of participantsEffectQuality
CITBUsual careRelative

(95% CI)
Absolute

(95% CI)
Final Cobb angles (degrees) at approximately 3 years after CITB pump insertion (better indicated by lower values)
1 study (Shilt 2008)50a50b-c-cVery low
Final Cobb angles (degrees) at approximately 3 years after CITB pump insertion (better indicated by lower values)
1 study (Senaran 2007)26d25e-f-fVery low
Mean annual progression of Cobb angles (degrees, better indicated by lower values)
1 study (Shilt 2008)50g50h-i-iVery low

CI confidence interval, CITB continuous pump-administered intrathecal baclofen, NS not (statistically) significant, P probability, SD standard deviation

a

Mean (SD) = 28 (20)

b

Mean (SD) = 27 (21)

c

MD 1 higher (7.14 lower to 9.14 higher) P = NS

d

Mean (SD) = 65.19 (24.74)

e

Mean (SD) = 73 (21.81)

f

MD 7.8 lower (20.95 lower to 5.33 higher) P = NS

g

Mean (SD) = 6.6 (11.3)

h

Mean 5.0 SD (6.1)

i

MD 1.6 lower (2 lower to 5.2 higher) P = NS

See the complete GRADE Table K.8.19 which accompanies this abbreviated version.

From: 8, Intrathecal baclofen

Cover of Spasticity in Children and Young People with Non-Progressive Brain Disorders
Spasticity in Children and Young People with Non-Progressive Brain Disorders: Management of Spasticity and Co-Existing Motor Disorders and Their Early Musculoskeletal Complications.
NICE Clinical Guidelines, No. 145.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Jul.
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