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Table K.4.12Evidence profile for serial casting compared with usual care in children with unilateral or bilateral spasticity; functioning assessment

Quality assessmentSummary of findings
No. of patientsEffectQuality
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsSerial castingUsual careRelative

(95% CI)
Absolute
Walking speed (metres/second, tridimensional gait analysis) (Change from baseline at 12 weeks) (Better indicated by higher values)
1 study (McNee 2007)randomised trialsserious1no serious inconsistencyno serious indirectnessserious2none9394-MD 0.03 lower (0.18 lower to 0.13 higher)5Low

CI confidence interval, MD mean difference

1

Randomisation, allocation concealment and outcome assessor details not provided

2

Total population less than 400, 95% confidence interval crosses null effect and is wide

3

Change from baseline at 12 weeks mean (standard deviation; SD) = -0.01 (0.1)

4

Change from baseline at 12 weeks mean (SD) = 0.02 (0.2)

5

p=NS reported

Randomisation, allocation concealment and outcome assessor details not provided

Total population less than 400, 95% confidence interval crosses null effect and is wide

Change from baseline at 12 weeks mean (standard deviation; SD) = -0.01 (0.1)

Change from baseline at 12 weeks mean (SD) = 0.02 (0.2)

p=NS reported

From: Appendix K, GRADE tables

Cover of Spasticity in Children and Young People with Non-Progressive Brain Disorders
Spasticity in Children and Young People with Non-Progressive Brain Disorders: Management of Spasticity and Co-Existing Motor Disorders and Their Early Musculoskeletal Complications.
NICE Clinical Guidelines, No. 145.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Jul.
Copyright © 2012, National Collaborating Centre for Women's and Children's Health.

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