Table K.4.1Evidence profile for active use therapy compared with no active use therapy in children with unilateral spasticity; joint movement assessment

Quality assessmentSummary of findings
No. of patientsEffectQuality
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsActive use therapyNo active use therapyRelative (95% CI)Absolute (95% CI)
Active range of movement (AROM) wrist extension at week 9 (Better indicated by higher values)
1 study (Aarts 2011)randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious1none2822-MD 4.5 higher (4.29 lower to 13.29 higher)*Moderate
AROM wrist extension at week 17 (Better indicated by higher values)
1 study (Aarts 2011)randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious2none2822-MD 3.1 higher (10.68 lower to 16.88 higher)*Moderate
Passive range of movement (PROM) wrist extension at week 9 (Better indicated by higher values)
1 study (Aarts 2011)randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious3none2822-MD 3.6 higher (0.46 lower to 7.66 higher)*Moderate
PROM wrist extension at week 17 (Better indicated by higher values)
1 study (Aarts 2011)randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious2none2822-MD 3.9 higher (0.57 lower to 8.37 higher)*Moderate
AROM elbow extension at week 9 (Better indicated by higher values)
1 study (Aarts 2011)randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious4none2822-MD 2.9 higher (2.72 lower to 8.52 higher)*Moderate
AROM elbow extension at week 17 (Better indicated by higher values)
1 study (Aarts 2011)randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious2none2822-MD 5.2 higher (0.52 lower to 10.92 higher)*Moderate
PROM elbow extension at week 9 (Better indicated by higher values)
1 study (Aarts 2011)randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious5none2822-MD 1.4 higher (1.76 lower to 4.56 higher)*Moderate
PROM elbow extension at week 17 (Better indicated by higher values)
1 study (Aarts 2011)randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessno serious imprecisionnone2822-MD 3.6 higher (0.76 to 6.44 higher)High

CI confidence interval, MD mean difference

*

Calculated by the NCC-WCH

1

Total population is under 400, 95% confidence interval crosses null effect and is wide. Effect size is reported as 0.25

2

Total population is under 400, 95% confidence interval crosses null effect and is wide

3

Total population is under 400, 95% confidence interval crosses null effect and is wide. Effect size is reported as 0.33

4

Total population is under 400, 95% confidence interval crosses null effect and is wide. Effect size is reported as 0.17

5

Total population is under 400, 95% confidence interval crosses null effect and is wide. Effect size is reported as 0.15

Calculated by the NCC-WCH

Total population is under 400, 95% confidence interval crosses null effect and is wide. Effect size is reported as 0.25

Total population is under 400, 95% confidence interval crosses null effect and is wide

Total population is under 400, 95% confidence interval crosses null effect and is wide. Effect size is reported as 0.33

Total population is under 400, 95% confidence interval crosses null effect and is wide. Effect size is reported as 0.17

Total population is under 400, 95% confidence interval crosses null effect and is wide. Effect size is reported as 0.15

From: Appendix K, GRADE tables

Cover of Spasticity in Children and Young People with Non-Progressive Brain Disorders
Spasticity in Children and Young People with Non-Progressive Brain Disorders: Management of Spasticity and Co-Existing Motor Disorders and Their Early Musculoskeletal Complications.
NICE Clinical Guidelines, No. 145.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Jul.
Copyright © 2012, National Collaborating Centre for Women's and Children's Health.

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