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Table 8.3Evidence profile for procalcitonin in babies about to start antibiotic treatment

Number of studiesNumber of babiesSensitivity (95% confidence interval)Specificity (95% confidence interval)Positive likelihood ratio (95% confidence interval)Negative likelihood ratio (95% confidence interval)Quality
PCT > 0.27 ng/ml in the prediction of infection within 10 days of birth, using blood culture and/or clinical diagnosis of infection as reference standard
1 (Franz 1999)16280 (66 to 91)53 (44 to 62)20.4Moderate
PCT > 0.50 ng/ml in the prediction of infection within 10 days of birth, using blood culture and/or clinical diagnosis of infection as reference standard
1 (Franz 1999)16257 (41 to 71)66 (57 to 74)20.7Moderate
PCT ≥ 2 ng/ml in the prediction of infection within 12 hours of birth, using blood culture or clinical infection as reference standard
1 (Resch 2003)68836120.3Moderate
PCT > 3.50 ng/ml in the prediction of infection within 10 days of birth, using blood culture and/or clinical diagnosis of infection as reference standard
1 (Franz 1999)16230 (18 to 46)91 (84 to 95)30.8Moderate
PCT > 5.75 ng/ml at presentation in the prediction of infection within 72 hours of birth, using blood culture or clinical infection as reference standard
1
(Bender 2008)
123686720.5Low
PCT ≥ 6 ng/ml in the prediction of infection within 12 hours of birth, using blood culture or clinical infection as reference standard
1 (Resch 2003)68779190.3Moderate
PCT ≥ 14 ng/ml in the prediction of infection within 12 hours of birth, using blood culture or clinical infection as reference standard
1 (Resch 2003)6863100NC0.4Moderate

NC not calculable, PCT procalcitonin

See the complete GRADE Table J 8.3

From: 8, Investigations before starting antibiotics in the baby

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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