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Table G.5

Bibliographic informationReason for exclusion
Ablow, R.C., Gross, I., Effmann, E.L., Uauy, R., Driscoll, S., The radiographic features of early onset Group B streptococcal neonatal sepsis, Radiology, 124, 771–777, 1977Not a diagnostic accuracy study; establishes the association between severity of radiographical findings and poor outcomes in babies with early-onset neonatal infection
Adib, M., Ostadi, V., Navaei, F., Saheb, Fosoul F., Oreizi, F., Shokouhi, R., Bakhshiani, Z., Evaluation of CD11b expression on peripheral blood neutrophils for early detection of neonatal sepsis, Iranian Journal of Allergy Asthma and Immunology, 6, 93–96, 2007Study conducted in Iran (not a geographical area of interest to the GDG)
Aktas, Tapisiz A, Ergenekon, E., Erbas, D., Oktem, M., Demirel, N., Gucuyener, K., Turkyilmaz, C., Onal, E., Atalay, Y., Interleukin-6 and nitric oxide levels in neonatal sepsis, Turkish Journal of Medical Sciences, 37, 261–266, 2007Study conducted in Turkey (not a geographical area specified in the review protocol)
Ali, A.M., Moaz, M.A., Ghoniem, E., bd El, Motaleb T., Sheri, N., Reliability of serum procalcitonin concentrations for the diagnosis of sepsis in neonates, Egyptian Journal of Immunology/Egyptian Association of Immunologists, 15, 75–84, 2008British Library unable to supply
Ammo, K., Salacity, G., CRP and ESR as a diagnostic marker in detection of neonatal sepsis, Pakistan Paediatric Journal, 32, 15–22, 2008British Library unable to supply
Andersen, J., Christensen, R., Hertel, J., Clinical features and epidemiology of septicaemia and meningitis in neonates due to Streptococcus agalactiae in Copenhagen county, Denmark: A 10 year survey from 1992 to 2001, Acta Paediatrica, International Journal of Paediatrics, 93, 1334–1339, 2004Not a diagnostic accuracy study
Apostolou, M., Dimitriou, H., Kaleyias, J., Perdikogianni, C., Stiakaki, E., Costalos, C., Kalmanti, M.C., Levels of soluble ICAM-1 in premature and full-term neonates with infection, Mediators of Inflammation, 11, 95–98, 2002Soluble intracellular adhesion molecule-1 is not an index test specified in the review protocol
Ashouri, N., Butler, J., Vargas-Shiraishi, O.M., Singh, J., Arrieta, A., Urinary tract infection in neonates: How aggressive a workup and therapy?, Infections in Medicine, #20, 98–102, 2003Study population aged 0–30 days with no separate data for early-onset neonatal infection reported
Bachur, R., Caputo, G.L., Bacteremia and meningitis among infants with urinary tract infections, Pediatric Emergency Care, 11, 280–284, 1995Study population comprised babies and children less than 2 years old with no separate data for early-onset neonatal infection reported
Bachur, R.G., Harper, M.B., Predictive model for serious bacterial infections among infants younger than 3 months of age, Pediatrics, 108, 311–316, 2001Study population is babies less than 3 months old; no separate data on early-onset neonatal infection reported
Barnett, E.D., Bauchner, H., Teele, D.W., Klein, J.O., Serious bacterial infections in febrile infants and children selected for lumbar puncture, Pediatric Infectious Disease Journal, 13, 950–953, 1994Study population aged 4 days to 17 years; not relevant to the review question
Becker, J.A., Ascher, D.P., Mendiola, J., Yoder, B., Weisse, M., Waecker, N., Heroman, W.M., Davis, C., Fajardo, J.E., Fischer, G.W., False-negative urine latex particle agglutination testing in neonates with group B streptococcal bacteremia. A function of improper test implementation?, Clinical Pediatrics, 32, 467–471, 1993Not a true diagnostic accuracy study; study population consisted only of babies with positive blood cultures for group B streptococcus
Benitz, W.E., Adjunct laboratory tests in the diagnosis of early-onset neonatal sepsis, Clinics in Perinatology, 37, 421–438, 2010Review article with no new data
Benuck, I., David, R.J., Sensitivity of published neutrophil indexes in identifying newborn infants with sepsis, Journal of Pediatrics, 103, 961–963, 1983This is not a diagnostic accuracy study; it is a review of different protocols for measuring neonatal leukocyte count
Bhandari, V., Wang, C., Rinder, C., Rinder, H., Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker, Pediatrics, 121, 129–134, 2008Mean ages in sepsis and control groups were 22.1 days and 12.3 days, respectively; not a population relevant to the review protocol
Bhartiya, D., Kapadia, C., Sanghvi, K., Singh, H., Kelkar, R., Merchant, R., Preliminary studies on IL-6 levels in healthy and septic Indian neonates, Indian Pediatrics, 37, 1361–1367, 2000Study conducted in India (not a geographical area specified in the review protocol)
Blommendahl, J., Janas, M., Laine, S., Miettinen, A., Ashorn, P., Comparison of procalcitonin with CRP and differential white blood cell count for diagnosis of culture-proven neonatal sepsis, Scandinavian Journal of Infectious Diseases, 34, 620–622, 2002Study population consisted of all neonates with suspected bacterial infection but no data were reported for babies with early-onset infection
Bonsu, B.K., Chb, M., Harper, M.B., Identifying febrile young infants with bacteremia: is the peripheral white blood cell count an accurate screen?, Annals of Emergency Medicine, 42, 216–225, 2003Study population consisted of babies aged 0–89 days; no separate data for early-onset neonatal infection reported
Boo, N.Y., Nor Azlina, A.A., Rohana, J., Usefulness of a semi-quantitative procalcitonin test kit for early diagnosis of neonatal sepsis, Singapore Medical Journal, 49, 204–208, 2008Study conducted in Malaysia (not a geographical area specified in the review protocol)
Brozanski, B.S., Jones, J.G., Krohn, M.J., Jordan, J.A., Use of polymerase chain reaction as a diagnostic tool for neonatal sepsis can result in a decrease in use of antibiotics and total neonatal intensive care unit length of stay, Journal of Perinatology, 26, 688–692, 2006No diagnostic test accuracy data reported (study estimates the number of antibiotic doses and days in the neonatal intensive care unit that could have been avoided in babies with presumed early-onset sepsis, negative blood culture results and negative polymerase chain reaction test results had the polymerase chain reaction results been available within 18 hours of admission to the unit)
Buck, C., Bundschu, J., Gallati, H., Bartmann, P., Pohlandt, F., Interleukin-6: a sensitive parameter for the early diagnosis of neonatal bacterial infection, Pediatrics, 93, 54–58, 1994Study population consisted of all neonates with suspected bacterial infection with no data reported for early-onset neonatal infection
Cancelier, A.C., Petronilho, F., Reinke, A., Constantino, L., MacHado, R., Ritter, C., Dal-Pizzol, F., Inflammatory and oxidative parameters in cord blood as diagnostic of early-onset neonatal sepsis: A case–control study, Pediatric Critical Care Medicine, 10, 467–471, 2009Cord blood examination is not one of the index tests listed in the review protocol
Centre for Reviews and Dissemination., Accuracy of C-reactive protein determination in predicting chorioamnionitis and neonatal infection in pregnant women with premature rupture of membranes: a systematic review (Structured abstract), Database of Abstracts of Reviews of Effects, -, 2011Structured abstract for a systematic review that did not identify any prospective cohort studies for inclusion in relation to diagnostic test accuracy of C-reactive protein for identifying babies with neonatal sepsis
Centre for Reviews and Dissemination., Accuracy of leukocyte indices and C-reactive protein for diagnosis of neonatal sepsis: a critical review (Structured abstract), Database of Abstracts of Reviews of Effects, -, 2010Study included babies with early-and late-onset neonatal infection with no separate data reported for early-onset infection
Centre for Reviews and Dissemination., Accuracy of leukocyte indices and C-reactive protein for diagnosis of neonatal sepsis: a critical review (Structured abstract), Database of Abstracts of Reviews of Effects, -, 2011Structured abstract for a systematic review that did not specifically evaluate the diagnostic test accuracy of leukocyte indices or C-reactive protein for the prediction of early-onset neonatal sepsis
Cetinkaya, M., Ozkan, H., Koksal, N., Celebi, S., Hacimustafaoglu, M., Comparison of serum amyloid A concentrations with those of C-reactive protein and procalcitonin in diagnosis and follow-up of neonatal sepsis in premature infants, Journal of Perinatology, 29, 225–231, 2009Study conducted in Turkey (not a geographical area specified in the review protocol)
Chan, D.K., Ho, L.Y., Usefulness of C-reactive protein in the diagnosis of neonatal sepsis, Singapore Medical Journal, 38, 252–255, 1997Study conducted in Singapore (not a geographical area specified in the review protocol)
Chen, C.J., Lo, Y.F., Huang, M.C., Chung, R.L., Tang, R.B., Wu, K.G., A model for predicting risk of serious bacterial infection in febrile infants younger than 3 months of age, Journal of the Chinese Medical Association: JCMA, 72, 521–526, 2009Study conducted in Taiwan (not a geographical area specified in the review protocol)
Chen, L.H., Duan, Q.J., Cai, M.T., Wu, Y.D., Shang, S.Q., Rapid diagnosis of sepsis and bacterial meningitis in children with real-time fluorescent quantitative polymerase chain reaction amplification in the bacterial 16S rRNA gene, Clinical Pediatrics, 48, 641–647, 2009Study conducted in China (not a geographical area specified in the review protocol)
Chiu, C.H., Lin, T.Y., Bullard, M.J., Application of criteria identifying febrile outpatient neonates at low risk for bacterial infections, Pediatric Infectious Disease Journal, 13, 946–949, 1994Study conducted in Taiwan (not a geographical area specified in the review protocol)
DeCamp, L.R., Universal primer polymerase chain reaction can diagnose neonatal sepsis when performed before starting antibiotics, Journal of Pediatrics, 155, 146–147, 2009Commentary on research conducted in India; not a geographical area specified in the review protocol
Devi, A.C., Pushpa, A comparative study in sepsis and normal neonates-A microbiological perspective, Journal of Medical Sciences, 8, 515–518, 2008Study conducted in India (not a geographical area specified in the review protocol)
Dilli, D., Oguz, S.S., Dilmen, U., Koker, M.Y., Kizilgun, M., Predictive values of neutrophil CD64 expression compared with interleukin-6 and C-reactive protein in early diagnosis of neonatal sepsis, Journal of Clinical Laboratory Analysis, 24, 363–370, 2010Study does not focus specifically on early-onset neonatal infection
Distefano, G., Curreri, R., Betta, P., Romeo, M.G., Amato, M., Procalcitonin serum levels in perinatal bacterial and fungal infection of preterm infants, Acta Paediatrica, 93, 216–219, 2004Blood was collected at 3, 7 and 10 days after birth; not useful for diagnosis of early-onset neonatal infection
Doron, M.W., Makhlouf, R.A., Katz, V.L., Lawson, E.E., Stiles, A.D., Increased incidence of sepsis at birth in neutropenic infants of mothers with preeclampsia, Journal of Pediatrics, 125, 452–458, 1994Not a diagnostic accuracy study
Doughty, L., Carcillo, J.A., Kaplan, S., Janosky, J., The compensatory anti-inflammatory cytokine interleukin 10 response in pediatric sepsis-induced multiple organ failure, Chest, 113, 1625–1631, 1998Study population aged 1 day to 18 years; no separate data for early-onset neonatal infection reported
Duffy, L.C., Zielezny, M.A., Carrion, V., Griffiths, E., Dryja, D., Hilty, M., Cummings, J., Morin, F., Bacterial toxins and enteral feeding of premature infants at risk for necrotizing enterocolitis, Advances in Experimental Medicine and Biology, 501, 519–527, 2001Not a diagnostic accuracy study; necrotising enterocolitis not included in the scope for this guideline
Edgar, J.D., Wilson, D.C., McMillan, S.A., Crockard, A.D., Halliday, M.I., Gardiner, K.R., Rowlands, B.J., Halliday, H.L., McNeill, T.A., Predictive value of soluble immunological mediators in neonatal infection, Clinical Science, 87, 165–171, 1994Study population includes babies with early-and late-onset neonatal infection with no separate diagnostic accuracy data reported for early-onset infection
el-Sameea, E.R., Metwally, S.S., Mashhour, E., el-Bendary, A., Hassan, A.M., el-Sharkawy, H., el-Shennawy, F.A., Evaluation of natural killer cells as diagnostic markers of early onset neonatal sepsis: comparison with C-reactive protein and interleukin-8, Egyptian Journal of Immunology/Egyptian Association of Immunologists, 11, 91–102, 2004Study conducted in Egypt (not a geographical area of interest to the GDG)
Elwan, A.E., Zarouk, W.A., Diagnosis of neonatal bacterial sepsis by polymerase chain reaction, Journal of Biological Sciences, 9, 533–540, 2009Study conducted in Egypt (not a geographical area specified in the review protocol)
Faix, R.G., Utility of complete blood count and blood culture screening to diagnose neonatal sepsis in the asymptomatic at-risk newborn, Journal of Pediatrics, 143, 686–687, 2003Commentary on an included article (Ottolini 2003) which does not provide any additional information relevant to the review
Fendler, W.M., Piotrowski, A.J., Procalcitonin in the early diagnosis of nosocomial sepsis in preterm neonates, Journal of Paediatrics and Child Health, 44, 114–118, 2008Study population consists of babies more than 72 hours after birth; not relevant to the diagnosis of early-onset neonatal infection
Fowlie, P.W., Schmidt, B., Diagnostic tests for bacterial infection from birth to 90 days - A systematic review, Archives of Disease in Childhood: Fetal and Neonatal Edition, 78, F92–F98, 1998Systematic review of diagnostic tests for bacterial infection from birth to 90 days; no subgroup analysis reported for early-onset neonatal infection
Franz, A.R., Sieber, S., Pohlandt, F., Kron, M., Steinbach, G., Whole blood interleukin 8 and plasma interleukin 8 levels in newborn infants with suspected bacterial infection, Acta Paediatrica, International Journal of Paediatrics, 93, 648–653, 2004Study included babies with early-and late-onset infection with no separate data reported for early-onset infection
Franz, A.R., Steinbach, G., Kron, M., Pohlandt, F., Reduction of unnecessary antibiotic therapy in newborn infants using interleukin-8 and C-reactive protein as markers of bacterial infections, Pediatrics, 104, 447–453, 1999Study relates to late-onset neonatal bacterial infection(babies aged > 72 hours)
Golden, S.M., Stamilio, D.M., Faux, B.M., la Cruz, W.P., Shoemaker, C.T., Blackmon, C.L., Stassen, S.D., Clark, V.M., Smith, J.W., Johnson, O.L., Evaluation of a real-time fluorescent PCR assay for rapid detection of Group B Streptococci in neonatal blood, Diagnostic Microbiology and Infectious Disease, 50, 7–13, 2004Methodological study of a diagnostic test rather than diagnostic accuracy study in clinical settings
Greenberg, D.N., Ascher, D.P., Yoder, B.A., Hensley, D.M., Heiman, H.S., Keith, J.F., III, Sensitivity and specificity of rapid diagnostic tests for detection of group B streptococcal antigen in bacteremic neonates, Journal of Clinical Microbiology, 33, 193–198, 1995Study included babies with early-and late-onset infection with no separate data reported for early-onset infection
Gupta, S.K., Sharma, U., Gupta, M.L., Sharma, D.K., Acridine orange stain--a rapid method for diagnosis of neonatal septicemia, Indian Pediatrics, 26, 153–155, 1989Study conducted in India (not a geographical area specified in the review protocol)
Ipek, I.O., Saracoglu, M., Bozaykut, A., Alpha1-acid glycoprotein for the early diagnosis of neonatal sepsis, Journal of Maternal-Fetal and Neonatal Medicine, 23, 617–621, 2010Study conducted in Turkey (not a geographical area specified in the review protocol)
Jordan, J.A., Durso, M.B., Comparison of 16S rRNA gene PCR and BACTEC 9240 for detection of neonatal bacteremia, Journal of Clinical Microbiology, 38, 2574–2578, 2000Study population consisted of all neonates with suspected bacterial infection but no data were reported for babies with early-onset infection
Jordan, J.A., Durso, M.B., Real-time polymerase chain reaction for detecting bacterial DNA directly from blood of neonates being evaluated for sepsis, Journal of Molecular Diagnostics, 7, 575–581, 2005Methodological study of a diagnostic test rather than diagnostic accuracy study in clinical settings
Kennon, C., Overturf, G., Bessman, S., Sierra, E., Smith, K.J., Brann, B., Granulocyte colony-stimulating factor as a marker for bacterial infection in neonates, Journal of Pediatrics, 128, 765–769, 1996Study included babies with both early-and late-onset infection with no separate data on early-onset infection
Kocaba&#x015F, E, lu, A., Aksaray, N., lu, G., Seyhun, Y., Yaman, A., Role of procalcitonin, C-reactive protein, interleukin-6, interleukin-8 and tumor necrosis factor-alpha in the diagnosis of neonatal sepsis, Turkish Journal of Pediatrics, 49, 7–20, 2007Study conducted in Turkey (not a geographical area specified in the review protocol)
Krishna, B.V., Nadgir, S.D., Tallur, S.S., Immunoglobulin-M estimation and C-reactive protein detection in neonatal septicemia, Indian Journal of Pathology and Microbiology, 43, 35–40, 2000Study conducted in India (not a geographical area specified in the review protocol)
Laborada, G., Rego, M., Jain, A., Guliano, M., Stavola, J., Ballabh, P., Krauss, A.N., Auld, P.A., Nesin, M., Diagnostic value of cytokines and C-reactive protein in the first 24 hours of neonatal sepsis, American Journal of Perinatology, 20, 491–501, 2003Study included babies with early-and late-onset neonatal infection but no separate diagnostic accuracy data for early-onset infection were reported
Leibovich, M., Gale, R., Slater, P.E., Usefulness of the gastric aspirate examination in the diagnosis of neonatal infection, Tropical and Geographical Medicine, 39, 15–17, 1987Study conducted in Israel a geographical area specified in the review protocol)
Magudumana, M.O., Ballot, D.E., Cooper, P.A., Trusler, J., Cory, B.J., Viljoen, E., Carter, A.C., Serial interleukin 6 measurements in the early diagnosis of neonatal sepsis, Journal of Tropical Pediatrics, 46, 267–271, 2000Study population included early-and late-onset neonatal infection with no separate data for early-onset infection reported
Makhoul, I.R., Smolkin, T., Sujov, P., Kassis, I., Tamir, A., Shalginov, R., Sprecher, H., PCR-based diagnosis of neonatal staphylococcal bacteremias, Journal of Clinical Microbiology, 43, 4823–4825, 2005Study conducted in Israel (not a geographical area specified in the review protocol)
Manucha, V., Rusia, U., Sikka, M., Faridi, M.M., Madan, N., Utility of haematological parameters and C-reactive protein in the detection of neonatal sepsis, Journal of Paediatrics and Child Health, 38, 459–464, 2002Study conducted in India (not a geographical area specified in the review protocol)
Mathers, N.J., Pohlandt, F., Diagnostic audit of C-reactive protein in neonatal infection, European Journal of Pediatrics, 146, 147–151, 1987Study included babies within 648 hours (27 days) of birth with no separate data reported for early-onset neonatal infection
McIntyre, P., Isaacs, D., Lumbar puncture in suspected neonatal sepsis, Journal of Paediatrics and Child Health, 31, 1–2, 1995Short review article with no primary data reported
Mehr, S.S., Doyle, L.W., Rice, G.E., Vervaart, P., Henschke, P., Interleukin-6 and interleukin-8 in newborn bacterial infection, American Journal of Perinatology, 18, 313–324, 2001Study population included babies with late-onset infection, with no separate results reported for early-onset infection
Misra, P.K., Kumar, R., Malik, G.K., Mehra, P., Awasthi, S., Simple hematological tests for diagnosis of neonatal sepsis, Indian Pediatrics, 26, 156–160, 1989Study conducted in India (not a geographical area specified in the review protocol)
Namdeo, U.K., Singh, H.P., Rajput, V.J., Kushwaha, J.S., Hematological indices for early diagnosis of neonatal septicemia, Indian Pediatrics, 22, 287–292, 1985Study conducted in India (not a geographical area specified in the review protocol)
Narasimha, A., Harendra, Kumar M, Significance of hematological scoring system (HSS) in early diagnosis of neonatal sepsis, Indian Journal of Hematology and Blood Transfusion, 27, 14–17, 2011Study conducted in India (not a geographical area specified in the review protocol)
Noor, M.K., Shahidullah, M., Mutanabbi, M., Barua, C., Mannan, M.A., Afroza, S., Comparison between CRP and IL-6 as early markers of neonatal sepsis, Mymensingh Medical Journal: MMJ, 17, S72–S76, 2008British Library unable to supply
Ohlin, A., ckman, A., rkqvist, M., lling, P., Jurstrand, M., Schollin, J., Real-time PCR of the 16S-rRNA gene in the diagnosis of neonatal bacteraemia, Acta Paediatrica, 97, 1376–1380, 2008Study included early-and late-onset neonatal infection with no separate results for early-onset infection reported
Park, K.H., Yoon, B.H., Shim, S.S., Jun, J.K., Syn, H.C., Amniotic fluid tumor necrosis factor-alpha is a marker for the prediction of early-onset neonatal sepsis in preterm labor, Gynecologic and Obstetric Investigation, 58, 84–90, 2004Study investigated a test carried out in women, not babies
Pauli, I., Jr., Shekhawat, P., Kehl, S., Sasidharan, P., Early detection of bacteremia in the neonatal intensive care unit using the new BACTEC system, Journal of Perinatology, 19, 127–131, 1999Descriptive study of a test with no diagnostic accuracy data
Polin, J.I., Knox, I., Baumgart, S., Campman, E., Mennuti, M.T., Polin, R.A., Use of umbilical cord blood culture for detection of neonatal bacteremia, Obstetrics and Gynecology, 57, 233–237, 1981Umbilical cord blood culture is not an index test specified in the review protocol
Pourcyrous, M., Bada, H.S., Korones, S.B., Barrett, F.F., Jennings, W., Lockey, T., Acute phase reactants in neonatal bacterial infection, Journal of Perinatology, 11, 319–325, 1991Study included babies more than 1 month old with no separate data for babies with early-onset neonatal infection
Pourcyrous, M., Bada, H.S., Korones, S.B., Baselski, V., Wong, S.P., Significance of serial C-reactive protein responses in neonatal infection and other disorders, Pediatrics, 92, 431–435, 1993Study included babies aged older than 1 month with no separate data reported for early-onset neonatal infection
Rozycki, H.J., Stahl, G.E., Baumgart, S., Impaired sensitivity of a single early leukocyte count in screening for neonatal sepsis, Pediatric Infectious Disease Journal, 6, 440–442, 1987Not a true diagnostic accuracy study; study population consisted only of babies with blood culture-proven sepsis
Salzer, H.R., Pollak, A., Herkner, K., Weninger, M., Schemper, W., Value of measurement of neutrophil elastase-alpha 1 proteinase inhibitor levels in the early diagnosis of neonatal infection, European Journal of Clinical Microbiology and Infectious Diseases, 12, 553–556, 1993Study describing a test that is not currently used in clinical practice
Sanchez, P.J., Siegel, J.D., Cushion, N.B., Threlkeld, N., Significance of a positive urine group B streptococcal latex agglutination test in neonates, Journal of Pediatrics, 116, 601–606, 1990Study did not report diagnostic accuracy data
Santana, C., Guindeo, M.C., lez, G., oz, F., Saavedra, P., nech, E., Cord blood levels of cytokines as predictors of early neonatal sepsis, Acta Paediatrica, 90, 1176–1181, 2001Cord blood levels of cytokines: not an index test specified in the review protocol
Santana, Reyes C., oz, F., Reyes, D., lez, G., Dominguez, C., Domenech, E., Role of cytokines (interleukin-1beta, 6, 8, tumour necrosis factor-alpha, and soluble receptor of interleukin-2) and C-reactive protein in the diagnosis of neonatal sepsis, Acta Paediatrica, 92, 221–227, 2003Study included early-and late-onset neonatal infection with no separate data on early-onset infection reported
Selva, L., Esteva, C., Gene, A., de Sevilla, M.F., Hernandez-Bou, S., Munoz-Almagro, C., Direct detection of Streptococcus pneumoniae in positive blood cultures by real-time polymerase chain reaction, Diagnostic Microbiology and Infectious Disease, 66, 204–206, 2010Study population is children and young people younger than 18 years
Shang, S., Chen, G., Wu, Y., DU, L., Zhao, Z., Rapid diagnosis of bacterial sepsis with PCR amplification and microarray hybridization in 16S rRNA gene, Pediatric Research, 58, 143–148, 2005Study conducted in China (not a geographical area specified in the review protocol)
Shaoul, R., Lahad, A., Tamir, A., Lanir, A., Srugo, I., C reactive protein (CRP) as a predictor for true bacteremia in children, Medical Science Monitor, 14, CR255–CR261, 2008Study conducted in Israel (not a geographical area specified in the review protocol)
Sharma, A., Kutty, C.V., Sabharwal, U., Rathee, S., Mohan, H., Evaluation of sepsis screen for diagnosis of neonatal septicemia, Indian Journal of Pediatrics, 60, 559–563, 1993Study carried out in India (not a geographical area specified in the review protocol)
Shenoy, S., Antony, G., Shenoy, U.V., Value of superficial cultures in diagnosing neonatal sepsis, Indian Journal of Pediatrics, 67, 337–338, 2000Study conducted in India (not a geographical area specified in the review protocol)
Sherwin, C., Broadbent, R., Young, S., Worth, J., McCaffrey, F., Medlicott, N.J., Reith, D., Utility of interleukin-12 and interleukin-10 in comparison with other cytokines and acute-phase reactants in the diagnosis of neonatal sepsis, American Journal of Perinatology, 25, 629–636, 2008Study included babies with early-and late-onset neonatal infection but did not report diagnostic accuracy data for early-onset infection
Spear, M.L., Stefano, J.L., Fawcett, P., Proujansky, R., Soluble interleukin-2 receptor as a predictor of neonatal sepsis, Journal of Pediatrics, 126, 982–985, 1995Not an index test specified in the review protocol
Varsha, Rusia, U., Sikka, M., Faridi, M.M., Madan, N., Validity of hematologic parameters in identification of early and late onset neonatal infection, Indian Journal of Pathology and Microbiology, 46, 565–568, 2003Study conducted in India (not a geographical area specified in the review protocol)
Weirich, E., Rabin, R.L., Maldonado, Y., Benitz, W., Modler, S., Herzenberg, L.A., Herzenberg, L.A., Neutrophil CD11b expression as a diagnostic marker for early-onset neonatal infection, Journal of Pediatrics, 132, 445–451, 1998Not an index test specified in the review protocol
Wu, Y.D., Chen, L.H., Wu, X.J., Shang, S.Q., Lou, J.T., Du, L.Z., Zhao, Z.Y., Gram stain-specific-probe-based real-time PCR for diagnosis and discrimination of bacterial neonatal sepsis, Journal of Clinical Microbiology, 46, 2613–2619, 2008Study conducted in China (not a geographical area specified in the review protocol)
Yadav, A.K., Wilson, C.G., Prasad, P.L., Menon, P.K., Polymerase chain reaction in rapid diagnosis of neonatal sepsis, Indian Pediatrics, 42, 681–685, 2005Study conducted in India (not a geographical area specified in the review protocol)
Zeitoun, A.A., Gad, S.S., Attia, F.M., bu Maziad, A.S., Bell, E.F., Evaluation of neutrophilic CD64, interleukin 10 and procalcitonin as diagnostic markers of early-and late-onset neonatal sepsis, Scandinavian Journal of Infectious Diseases, 42, 299–305, 2010Study included babies with early-and late-onset neonatal infection but no separate diagnostic accuracy data on early-onset infection were reported

From: Appendix G, Excluded studies

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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