Table 6.14Evidence profile for erythromycin and amoxicillin plus clavulanic acid compared with placebo in women with preterm prelabour rupture of membranes

Number of studiesNumber of babies/womenEffectQuality
Erythromycin and amoxicillin plus clavulanic acidPlaceboRelative (95% confidence interval)Absolute (95% confidence interval)
Blood culture-proven infection in babies born within 14 days of randomisation
(Kenyon 2001a)
RR 0.7 (0.51 to 0.97)*21 fewer per 1000 (from 2 fewer to 34 fewer)*Very low
Proven necrotising enterocolitis
(Kenyon 2001a)
RR 3.43 (1.38 to 8.52)*12 more per 1000 (from 2 more to 37 more)*Low
Neonatal mortality
(Kenyon 2001a)
RR 0.97 (0.72 to 1.31)*2 fewer per 1000 (from 19 fewer to 21 more)*Low
Median gestational age at birth (days) (better indicated by lower values)
(Kenyon 2001a)
11891225-Median difference 1 higher*Moderate
Any functional impairment at age 7 years of vision, hearing, speaking, ambulation, dexterity, emotion, cognition or pain in children whose mothers had preterm prelabour rupture of membranes
(Kenyon 2008a)
RR 1.01 (0.89 to 1.14)4 more per 1000 (from 43 fewer to 55 more)*Moderate

RR relative risk


Calculated by the NCC-WCH technical team from data reported in the article

See the complete GRADE Table J 6.14

Calculated by the NCC-WCH technical team from data reported in the article

From: 6, Intrapartum antibiotics

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.