Table 6.12Evidence profile for erythromycin (with or without amoxicillin plus clavulanic acid) compared with placebo (with or without amoxicillin plus clavulanic acid) in women with preterm prelabour rupture of membranes

Number of studiesNumber of babies/womenEffectQuality
Erythromycin (with or without amoxicillin plus clavulanic acid)Placebo (with or without amoxicillin plus clavulanic acid)Relative (95% confidence interval)Absolute (95% confidence interval)
Blood culture-proven infection in babies born within 14 days of randomisation
1
(Kenyon 2001a)
119/2379
(5.0%)
148/2430
(6.1%)
RR 0.82 (0.65 to 1.04)*11 fewer per 1000 (from 21 fewer to 2 more)*Very low
Proven necrotising enterocolitis
1
(Kenyon 2001a)
31/2379
(1.3%)
30/2430
(1.2%)
RR 1.06 (0.64 to 1.74)*1 more per 1000 (from 4 fewer to 9 more)*Low
Neonatal mortality
1
(Kenyon 2001a)
147/2379
(6.2%)
161/2430
(6.6%)
RR 0.93 (0.75 to 1.16)*5 fewer per 1000 (from 17 fewer to 11 more)*Moderate
Median gestational age at birth (days) (better indicated by higher values)
1
(Kenyon 2001a)
23792430-Median difference 0*Moderate
Any functional impairment at age 7 years of vision, hearing, speaking, ambulation, dexterity, emotion, cognition or pain in children whose mothers had preterm prelabour rupture of membranes
1
(Kenyon 2008a)
594/1551
(38.3%)
655/1620
(40.4%)
RR 0.95 (0.87 to 1.03)*20 fewer per 1000 (from 53 fewer to 12 more)*Moderate
Overall behavioural difficulties at age 7 years in children whose mothers had preterm prelabour rupture of membranes
1
(Kenyon 2008a)
310/1551
(20%)
340/1620
(21%)
RR 0.95 (0.83 to 1.09)*10 fewer per 1000 (from 36 fewer to 19 more)*Moderate
Cerebral palsy reported by parents of children at age 7 years whose mothers had preterm prelabour rupture of membranes
1
(Kenyon 2008a)
46/1590
(2.9%)
41/1671
(2.5%)
RR 1.18 (0.78 to 1.79)*4 more per 1000 (from 5 fewer to 19 more)*Low
Seizures reported by parents of children at age 7 years whose mothers had preterm prelabour rupture of membranes
1
(Kenyon 2008a)
101/1590
(6.4%)
107/1671
(6.4%)
RR 0.99 (0.76 to 1.29)*1 fewer per 1000 (from 15 fewer to 19 more)*Low
Wheezing in last year reported by parents of children at age 7 years whose mothers had preterm prelabour rupture of membranes
1
(Kenyon 2008a)
305/1590
(19.2%)
320/1671
(19.2%)
RR 1.00 (0.87 to 1.15)*0 fewer per 1000 (from 25 fewer to 29 more)*Moderate

RR relative risk

*

Calculated by the NCC-WCH technical team from data reported in the article

See the complete GRADE Table J 6.12

Calculated by the NCC-WCH technical team from data reported in the article

From: 6, Intrapartum antibiotics

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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