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Table 5.8Evidence profile for diagnostic test accuracy of maternal group B streptococcus colonisation for predicting early-onset neonatal infection in the first 7 days of life

Number of studiesNumber of babiesSensitivity (95% confidence interval)Specificity (95% confidence interval)Positive likelihood ratio (95% confidence interval)Negative likelihood ratio (95% confidence interval)Quality
Maternal group B streptococcus colonisation (for prediction of culture-proven infection)
1 (Yancey 1996)82360.0
(35.2 to 84.8)*
74.4
(71.4 to 77.4)*
2.34
(1.52 to 3.60)*
0.54
(0.29 to 1.00)*
Low
Maternal group B streptococcus colonisation (for prediction of clinical infectionc)
1 (Yancey 1996)82342.2
(33.2 to 51.2)*
76.4
(73.3 to 79.5)*
1.79
(1.39 to 2.30)*
0.76
(0.64 to 0.89)*
Moderate
Maternal antenatal group B streptococcus colonisation (for prediction of suspected infection)
Heavy colonisation
1 (Bobitt 1985)7182.47
(0.30 to 8.64)*
94.7
(92.6 to 96.3)*
0.46
(0.12 to 1.67)*
1.03
(0.97 to 1.05)*
Moderate
Light colonisation
1 (Bobitt 1985)7186.17
(0.93 to 11.4)*
89.6
(87.2 to 92.1)*
0.59
(0.25 to 1.44)*
1.05
(0.98 to 1.11)*
Moderate
Maternal intrapartum group B streptococcus colonisation (for prediction of suspected infection)
Heavy colonisation
1 (Bobitt 1985)7182.47
(0.30 to 8.64)*
97.5
(96.0 to 98.6)*
0.98
(0.25 to 3.71)*
1.00
(0.95 to 1.02)*
Moderate
Light colonisation
1 (Bobitt 1985)7186.17
(0.93 to 11.4)*
95.6
(94.0 to 97.2)*
1.40
(0.56 to 3.53)*
0.98
(0.93 to 1.04)*
Moderate
*

Calculated by the NCC-WCH technical team from data reported in the article

See the complete GRADE Table J 5.8

Calculated by the NCC-WCH technical team from data reported in the article

From: 5, Risk factors for infection and clinical indicators of possible infection

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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