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Table 5.13Evidence profile for diagnostic test accuracy of the total number of clinical signs present for predicting blood-culture-positive infection in preterm babies (≤ 31 weeks’ gestation) in the first 28 days of life

Number of studiesNumber of babiesSensitivity (95% confidence interval)Specificity (95% confidence interval)Positive likelihood ratio (95% confidence interval)Negative likelihood ratio (95% confidence interval)Quality
≥ 0 signs
1 (Modi 2009)220100 (NC)0.00 (NC)1.00* (NC)NC (NC)Very low
≥ 1 sign
1 (Modi 2009)22088.9 (NC)62.0 (NC)2.34* (NC)0.18* (NC)Very low
≥ 2 signs
1 (Modi 2009)22069.7 (NC)82.9 (NC)4.08* (NC)0.37* (NC)Very low
≥ 3 signs
1 (Modi 2009)22054.6 (NC)91.8 (NC)6.66* (NC)0.49* (NC)Very low
≥ 4 signs
1 (Modi 2009)22035.4 (NC)95.8 (NC)8.43* (NC)0.67* (NC)Very low

NC not calculable


Calculated by the NCC-WCH technical team from data reported in the article

See the complete GRADE Table J 5.13

Calculated by the NCC-WCH technical team from data reported in the article

From: 5, Risk factors for infection and clinical indicators of possible infection

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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