Table 9.12Evidence profile for amikacin given every 24 hours (15 mg/kg/dose) compared with amikacin given every 12 hours (7.5 mg/kg/dose) in near-term and term babies (≥ 34 weeks’ gestation) with suspected neonatal infection in the first 2 days of life; all babies also received ampicillin every 12 hoursa

Number of studiesNumber of babiesEffectQuality
Amikacin every 24 hours (15 mg/kg/dose)Amikacin every 12 hours (7.5 mg/kg/dose)Relative (95% confidence interval)Absolute (95% confidence interval)
Cure rates for neonatal infection
1
(Langhendries 1993)
10/10
(100%)
12/12
(100%)
RR 1.00
(0.84 to 1.18)
0 fewer per 1000
(160 fewer to 180 more)*
Low
Mortality
1
(Langhendries 1993)
0/10
(0%)
0/12
(0%)
NCNCLow
Kidney damage (nephrotoxicity)a
1
(Langhendries 1993)
0/10
(0%)
0/12
(0%)
NCNCLow
Hearing damage (ototoxicity)b
1
(Langhendries 1993)
0/10
(0%)
0/12
(0%)
NCNCLow

NC not calculable, RR relative risk

*

Calculated by the NCC-WCH technical team from data reported in the article

a

Urinary levels of four low molecular weight proteins (albumin, beta-2-microglobulin, retinol binding proteins and Clara cell protein) and four kidney-derived enzymes (gamma-glutamyltransferase, alkaline phosphatase, alanine aminopeptidase and N-acetyl-beta-D-glucosaminidase) were used to assess damage to and functional integrity of proximal renal tubules, respectively. Fractional excretion of sodium and levels of phospholipid were also measured

b

Ototoxicity was assessed using brainstem auditory evoked potentials (BEAPs) performed on day 0 and repeated on days 6 and 9

See the complete GRADE Table J 9.12

Calculated by the NCC-WCH technical team from data reported in the article

Urinary levels of four low molecular weight proteins (albumin, beta-2-microglobulin, retinol binding proteins and Clara cell protein) and four kidney-derived enzymes (gamma-glutamyltransferase, alkaline phosphatase, alanine aminopeptidase and N-acetyl-beta-D-glucosaminidase) were used to assess damage to and functional integrity of proximal renal tubules, respectively. Fractional excretion of sodium and levels of phospholipid were also measured

Ototoxicity was assessed using brainstem auditory evoked potentials (BEAPs) performed on day 0 and repeated on days 6 and 9

From: 9, Antibiotics for suspected infection

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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