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Table 13.15Results of testing and treatment strategies for suspected sepsis assuming 12% of live births are suspected of having sepsis

Testing and treatment strategy for suspected sepsisCostQALYsIncremental costIncremental QALYsICER
Strategy 1: CRP tests on 3consecutive days with 3 days of antibiotics£158,760,09220,183.85£58,845,370−3.00Dominated
Strategy 2: CRP tests on 2 consecutive days with 36 hours of antibiotics£99,914,72220,186.85£11,928,0027.48£1,593,649
Strategy 3: CRP tests at presentation and at 24hours, with 36 hours of antibiotics£94,635,79520,178.74£6,649,075−0.62Dominated
Strategy 4: CRP tests at presentation and at 24 hours, only 24 hours result used for diagnosis, with 36 hours of antibiotics£87,986,72020,179.37---

CRP C-reactive protein, ICER incremental cost effectiveness ratio, QALY quality adjusted life year

From: 13, Health economics

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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