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Table 4.45 year overall survival

No of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsQuality
5-year survival
121observational studiesserious2no serious inconsistencyno serious indirectnessno serious imprecisionnoneVery Low
1

A total of 11 studies in the systematic review reported on 5 year survival and an additional study (Moug et al, 2010) published after the systematic review also reported 5 year survival and was included in the evidence assessment and forest plot.

2

All studies included in the systematic review (Hillingso et al, 2009) were retrospective controlled studies with 2 studies based on prospective databases and the remainder on retrospective analysis of patient data. The methodological quality of the studies included in the systematic review was evaluated using the Newcastle-Ottawa scale and only studies with a score of 8 or more were included in the review; despite this as observational studies rather than randomised trials it is considered that there are serious limitations in study design.

A total of 11 studies in the systematic review reported on 5 year survival and an additional study (Moug et al, 2010) published after the systematic review also reported 5 year survival and was included in the evidence assessment and forest plot.

All studies included in the systematic review (Hillingso et al, 2009) were retrospective controlled studies with 2 studies based on prospective databases and the remainder on retrospective analysis of patient data. The methodological quality of the studies included in the systematic review was evaluated using the Newcastle-Ottawa scale and only studies with a score of 8 or more were included in the review; despite this as observational studies rather than randomised trials it is considered that there are serious limitations in study design.

From: 4, Management of Metastatic Disease

Cover of Colorectal Cancer
Colorectal Cancer: The Diagnosis and Management of Colorectal Cancer.
NICE Clinical Guidelines, No. 131.
National Collaborating Centre for Cancer (UK).
Copyright © 2011, National Collaborating Centre for Cancer.

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