This figure depicts the analytic framework that outlines the population, interventions and outcomes considered in the review. The above figure is a modified version of a larger framework depicting the impact of both screening and treatment for Hepatitis C in adults. This figure focuses on the screening portion of the framework. The population includes asymptomatic adults and pregnant women. The interventions include screening for HCV infection risk factors, screening for HCV antibody, diagnostic tests for work-up of treatable disease, pregnancy interventions, counseling against risky behaviors and immunization for other hepatitis infections. Outcomes include mortality, morbidity, quality of life and HCV transmission as well as harms of screening and/or workup.

Figure AAnalytic framework: Screening for hepatitis C virus infection in adults

HCV = hepatitis C virus; QOL = quality of life; SVR = sustained virologic response

Note: Portions in gray refer to Key Questions addressed in a separate review on antiviral treatments.53

a Nonpregnant and pregnant adults without abnormal lab values. Excluding people with HIV, transplant recipients, and patients with renal failure.

b HCV antibody testing with confirmatory HCV RNA testing as indicated.

c Interventions that may affect vertical transmission of HCV, such as cesarean section, amniocentesis, fetal monitoring, or others.

d Refers to eligibility for antiviral treatment based on viral and host factors.

From: Executive Summary

Cover of Screening for Hepatitis C Virus Infection in Adults
Screening for Hepatitis C Virus Infection in Adults [Internet].
Comparative Effectiveness Reviews, No. 69.
Chou R, Cottrell EB, Wasson N, et al.

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