Table 34Vomiting, nausea, emesis reported in acute migraine trials

InterventionAuthor, Yearn/NRisk (95% CI)
PlaceboCicek, 20041135/830.06 [0.03, 0.13]
Tek, 1987982/240.08, 0.02, 0.26]
Krymchantowski, 20031001/120.08 [0.01, 0.35]
Wendt, 20065715/1930.08 [0.05, 0.12]
Bigal, 20024310/300.33 [0.17, 0.51]
Mushet, 19965811/790.14 [0.08, 0.23]
Cady, 19916052/3700.14 [0.11, 0.18]
Silberstein, 2003633/610.05 [0.02, 0.14]
 Subtotal N=899/8520.11 [0.06, 0.14]
ButorphanolBelgrade, 19891105/190.26 [0.12, 0.49]
 Subtotal N=15/190.26 [0.12, 0.49]
ChlorpromazineCameron, 1995651/470.02 [0.00, 0.11]
Lane, 1989672/240.08 [0.02, 0.26]
Bigal, 2002431/300.03 [0.01, 0.17]
 Subtotal N=34/1010.03 [0.00, 0.07]
Standard abortive therapy plus dexamethasoneRowe, 2008214/640.06 [0.02, 0.15]
Donaldson, 2008769/570.16 [0.09, 0.27]
Jones, 20031092/340.06 [0.02, 0.19]
 Subtotal N=315/1550.09 [0.03, 0.14]
DHECarleton, 1998538/850.09 [0.05, 0.17]
Belgrade, 19891107/210.33 [0.17, 0.55]
Winner, 1996618/1520.05 [0.03, 0.10]
 Subtotal N=323/2580.11 [0.02, 0.20]
DiclofenacEngindeniz, 2005815/240.21 [0.09, 0.40]
 Subtotal N=15/240.21 [0.09, 0.40]
DroperidolSilberstein, 2003630/610.00 [0.00, 0.04]
Subtotal N=10/610.00 [0.00, 0.04]
HydroxyzineTek, 1987981/230.04 [0.01, 0.21]
 Subtotal N=11/230.04 [0.01, 0.21]
KetorolacDuarte, 1992943/250.12 [0.04, 0.30]
Larkin, 19921011/150.07 [0.01, 0.30]
 Subtotal N=24/400.10 [0.00, 0.19]
MeperidineCarleton, 19985320/850.24 [0.16, 0.34]
Larkin, 19921011/160.06 [0.01, 0.28]
Belgrade, 19891101/220.05 [0.01, 0.22]
 Subtotal N=322/1230.12 [0.00, 0.25]
Meperidine plus antihistiamineDuarte, 1992944/250.16 [0.06, 0.35]
Lane, 1989672/220.09 [0.03, 0.28]
Stiell, 19916610/370.27 [0.15, 0.43]
 Subtotal N=316/840.17 [0.07, 0.28]
MethotrimeprazineStiell, 1991668/370.22 [0.11, 0.37]
 Subtotal N=18/370.22 [0.11, 0.37]
MetoclopramideCicek, 20041136/850.07 [0.03, 0.15]
Jones, 19969111/290.38 [0.23, 0.56]
Cameron, 1995651/440.02 [0.00, 0.12]
 Subtotal N=318/1580.13 [0.00, 0.25]
Metoclopramide plus pethidineCicek, 200411311/840.13 [0.07, 0.22]
 Subtotal N=111/840.13 [0.07, 0.22]
Metoclopramide plus DHEEdwards, 20011047/200.35 [0.18, 0.57]
 Subtotal N=17/200.35 [0.18, 0.57]
NalbuphineTek, 1987986/230.26 [0.13, 0.46]
 Subtotal N=16/230.26 [0.13, 0.46]
Nalbuphine plus hydroxyzineTek, 1987985/240.21 [0.09, 0.40]
 Subtotal N=15/240.21 [0.09, 0.40]
ProchlorperazineCallan, 20087517/350.49 [0.33, 0.64]
Jones, 19969114/280.50 [0.33, 0.67]
 Subtotal N=231/630.49 [0.38, 0.61]
PromethazineCallan, 20087520/350.57 [0.41, 0.72]
 Subtotal N=120/350.57 [0.41, 0.72]
SumatriptanFriedman, 2006796/200.30 [0.15, 0.52]
Kelly, 1997321/200.05 [0.01, 0.24]
Wendt, 20065728/3840.07 [0.05, 0.10]
Mushet, 19965810/790.13 [0.07, 0.22]
Akpunonu, 19951068/880.09 [0.05, 0.17]
Cady, 19916068/5470.12 [0.10, 0.15]
Winner, 1996616/1580.04 [0.02, 0.08]
 Subtotal N=7127/12960.09 [0.05, 0.13]
TramadolEngindeniz, 2005817/230.30 [0.16, 0.51]
 Subtotal N=17/230.30 [0.16, 0.51]
Trimethobenzamide plus DHEFriedman, 2006791/200.05 [0.01, 0.24]
 Subtotal N=11/200.05 [0.01, 0.24]
ValproateEdwards, 20011046/200.30 [0.15, 0.52]
 Subtotal N=16/200.30 [0.15, 0.52]

CI = confidence interval; DHE = dihydroergotamine; N = number

From: Results

Cover of Acute Migraine Treatment in Emergency Settings
Acute Migraine Treatment in Emergency Settings [Internet].
Comparative Effectiveness Reviews, No. 84.
Sumamo Schellenberg E, Dryden DM, Pasichnyk D, et al.

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