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Table 4Strength of evidence for metoclopramide versus placebo

ComparisonOutcome (N Studies; N Patients)Strength of Evidence DomainsStrength of Evidence
ROBConsistencyDirectPrecision
Metoclopramide monotherapy vs. placeboPain intensity–VAS (5; 328)ModerateConsistentDirectPreciseModerate
Headache relief (1; 50)ModerateUnknownDirectPreciseInsufficient
Headache recurrence (1; 77)LowUnknownDirectImpreciseInsufficient
Metoclopramide+ DHE or dexamethasone vs. placeboPain improvement (1 RCT [3 arms]; 20)ModerateUnknownDirectPreciseInsufficient

DHE = dihydroergotamine; N = number; ROB = risk of bias; RCT = randomized control trial; VAS = visual analogue scale

From: Results

Cover of Acute Migraine Treatment in Emergency Settings
Acute Migraine Treatment in Emergency Settings [Internet].
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Sumamo Schellenberg E, Dryden DM, Pasichnyk D, et al.

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