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Cherry MG, Greenhalgh J, Osipenko L, et al. The Clinical Effectiveness and Cost-Effectiveness of Primary Stroke Prevention in Children with Sickle Cell Disease: A Systematic Review and Economic Evaluation. Southampton (UK): NIHR Journals Library; 2012 Nov. (Health Technology Assessment, No. 16.43.)

Appendix 8Outputs of sensitivity analyses

FIGURE 15. Varied parameter: 3-month probability of death when not on transfusion and TCD scan is < 200 cm/second (not due to stroke)

FIGURE 16. Varied parameter: 3-month probability of death when TCD scan is > 200 cm/second (not due to stroke) while off transfusion

FIGURE 17. Varied parameter: 3-month probability of death when TCD scan is > 200 cm/second (not due to stroke) while on transfusion

FIGURE 18. Varied parameter: probability of first stroke when on transfusion and TCD is > 200 cm/second (2–7 years age group)

FIGURE 19. Varied parameter: probability of first stroke when off transfusion and TCD is > 200 cm/second (2–7 years age group)

FIGURE 20. Varied parameter: 3-month probability of first stroke when on transfusion and TCD is > 200 cm/second (8–18 years age group)

FIGURE 21. Varied parameter: probability of first stroke when off transfusion and TCD is > 200 cm/second (8–18 years age group)

FIGURE 22. Varied parameter: probability of first stroke when on transfusion and TCD is > 200 cm/second (19–30 years age group)

FIGURE 23. Varied parameter: probability of first stroke when off transfusion and TCD is > 200 cm/second (19–30 years age group)

FIGURE 24. Varied parameter: probability of first stroke when on transfusion and TCD is > 200 cm/second (31+ years age group)

FIGURE 25. Varied parameter: probability of first stroke when off transfusion and TCD is > 200 cm/second (31+ years age group)

FIGURE 26. Varied parameter: probability of moving to a worse state post first stroke after one cycle

FIGURE 27. Varied parameter: cost of treatment for mild post-stroke state (initial)

FIGURE 28. Varied parameter: cost of treatment for moderate post stroke state (initial)

FIGURE 29. Varied parameter: cost of treatment for severe post-stroke state (initial)

FIGURE 30. Varied parameter: cost of treatment for severe post-stroke state (ongoing)

FIGURE 31. Probability of staying on transfusion until 18 years if TCD scan is > 200 cm/second

FIGURE 32. Varied parameter: utility loss per 3-month cycle of those pre-stroke TCD scan is > 200 cm/second and no transfusion compared with those with TCD scan < 200 cm/second (changing the utility value has no impact on CPSA)

FIGURE 33. Varied parameter: decrease in relative risk of SCD complications between those on transfusion and those off transfusion

FIGURE 34. Varied parameter: incremental cost of transfusion for alloimmunised patients

FIGURE 35. Varied parameter: percentage increase in cost of chelation (oral and injection)

FIGURE 36. Varied parameter: percentage increase in cost of transfusion (simple, exchange, combined)

FIGURE 37. Varied parameter: probability of death in adults not due to stroke on and off transfusion (age 19–30 years)

FIGURE 38. Varied parameter: probability of death in adults not due to stroke on and off transfusion (age 31+ years)

FIGURE 39. Varied parameter: probability TCD scan is < 200 cm/second per cycle

FIGURE 40. Varied parameter: disutility associated with oral chelation per cycle

FIGURE 41. Varied parameter: disutility associated with injection chelation per cycle

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Cover of The Clinical Effectiveness and Cost-Effectiveness of Primary Stroke Prevention in Children with Sickle Cell Disease: A Systematic Review and Economic Evaluation
The Clinical Effectiveness and Cost-Effectiveness of Primary Stroke Prevention in Children with Sickle Cell Disease: A Systematic Review and Economic Evaluation.
Health Technology Assessment, No. 16.43.
Cherry MG, Greenhalgh J, Osipenko L, et al.
Southampton (UK): NIHR Journals Library; 2012 Nov.

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