Table H.11.5GRADE findings for planned VBAC after 2 prior CS versus elective repeat CS after 2 prior CS

Quality assessmentSummary of findings
No. of womenEffect
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsPlanned vaginal birth

2 prior CS
Planned repeat CS

2 prior CS
Relative (95% CI)Absolute (95% CI)Quality
Blood transfusion
6 studies

(Tahseen & Griffiths, 2010)
observational studiesserious1no serious inconsistencyno serious indirectnessserious2none47/2,292

(2.1%)
172/10,277

(1.7%)
RR 1.22

(0.89 to 1.68)
Absolute risk difference:

4 more per 1000

(from 2 fewer to 11 more)*
Very low
Febrile morbidity
6 studies

(Tahseen & Griffiths, 2010)
observational studiesserious1no serious inconsistencyno serious indirectnessserious3none192/2,678

(7.2%)
630/9,858

(6.4%)
RR 1.12

(0.95 to 1.3)
Absolute risk difference:

8 more per 1000

(from 3 fewer to 19 more)*
Very low
Hysterectomy
7 studies

(Tahseen & Griffiths, 2010)
observational studiesserious1no serious inconsistencyno serious indirectnessno serious imprecisionnone9/1,747

(0.5%)
51/8,009

(0.6%)
RR 0.80

(0.40 to 1.61)
Absolute risk difference:

1 fewer per 1000

(from 4 fewer to 4 more)
Very low
1

poorly conducted meta-analysis (analysis software developed for RCTs used for observational studies without adjustment)

2

Heterogeneity across studies I2 = 64

3

Heterogeneity across studies I2 = 65

*

Calculated by NCC-WCH technical team

poorly conducted meta-analysis (analysis software developed for RCTs used for observational studies without adjustment)

Heterogeneity across studies I2 = 64

Heterogeneity across studies I2 = 65

Calculated by NCC-WCH technical team

From: Appendix H, GRADE tables

Cover of Caesarean Section
Caesarean Section.
NICE Clinical Guidelines, No. 132.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2011 Nov.
Copyright © 2011, National Collaborating Centre for Women's and Children's Health.

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