Table 1120.5% Chlorhexidine gluconate (CHG) in alcohol vs. 10% Povidone Iodine (PVP-I) in aqueous – Clinical study characteristics

OutcomeNumber of studiesDesignLimitationsInconsistencyIndirectnessImprecision
VAD related bacteraemia127,2642RCTSerious limitations(a)No serious inconsistencyNo serious indirectnessSerious imprecision(b)
VAD related local infection 1271RCTSerious limitations(a)No serious inconsistencyNo serious indirectnessSerious imprecision(b)
Catheter tip colonisation127,2642RCTSerious limitations(a)No serious inconsistencyNo serious indirectnessSerious imprecision(b)
VAD related phlebitis0RCT
Infection related mortality0RCT
Septicaemia0RCT
VAD line removal0RCT
a

Randomisation sequence generation and allocation concealment methods unclear.

b

Confidence intervals wide - crossed threshold(s) of clinically important harms and benefits.

Randomisation sequence generation and allocation concealment methods unclear.

Confidence intervals wide - crossed threshold(s) of clinically important harms and benefits.

From: 12, Vascular access devices

Cover of Infection: Prevention and Control of Healthcare-Associated Infections in Primary and Community Care
Infection: Prevention and Control of Healthcare-Associated Infections in Primary and Community Care: Partial Update of NICE Clinical Guideline 2.
NICE Clinical Guidelines, No. 139.
National Clinical Guideline Centre (UK).
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