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Table 13Alcohol handrub vs. antiseptic soap - Clinical study characteristics

OutcomeNumber of studiesDesignLimitationsInconsistencyIndirectnessImprecision
Log 10 CFU (Finger print technique)1521CrossoverSerious limitations(a)No serious inconsistencySerious indirectness(b)Serious imprecision(c)
CFU (Finger print technique)1021RCTSerious limitations(d)No serious inconsistencySerious indirectness(b)Serious imprecision(c)
CFU - 2 weeks (Glove juice technique)1441RCTSerious limitations(d)No serious inconsistencySerious indirectness(b)No serious imprecision
CFU - 4 weeks (Glove juice technique)1441RCTSerious limitations(d)No serious inconsistencySerious indirectness(b)No serious imprecision
Hand decontamination compliance0RCT
MRSA reduction or cross infection0RCT
C. diff reduction or cross infection0RCT
Removal of physical contamination0RCT
a

Crossover study, healthcare workers used both intervention and control.

b

Hospitals setting rather than community.

c

The relatively few events and few patients give wide confidence intervals around the estimate of effect. This makes it difficult to know the true effect size for this outcome.

d

Unclear allocation concealment.

Crossover study, healthcare workers used both intervention and control.

Hospitals setting rather than community.

The relatively few events and few patients give wide confidence intervals around the estimate of effect. This makes it difficult to know the true effect size for this outcome.

From: 6, Standard principles for hand decontamination

Cover of Infection: Prevention and Control of Healthcare-Associated Infections in Primary and Community Care
Infection: Prevention and Control of Healthcare-Associated Infections in Primary and Community Care: Partial Update of NICE Clinical Guideline 2.
NICE Clinical Guidelines, No. 139.
National Clinical Guideline Centre (UK).
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