Table 7Procalcitonin-guided antibiotic discontinuation in the critically ill/ventilator-associated pneumonia patients––GRADE evidence table

Outcome CategoryOutcomeNo. of Studies (Subjects)Risk of BiasConsistencyDirectnessPrecisionOverall Grade
Antibiotic useDuration5 RCTs (n=938)32-35,39LowConsistentDirectPreciseHigh
Days without ABTs (day 28)3 RCTs (n=801)32,35,39LowConsistentDirectPreciseHigh
Total exposure3 RCTs (n=801)32,35,39LowConsistentDirectPreciseHigh
MortalityIn-hospital, overall or 28 day5 RCTs (n=938)32-35,39LowConsistentDirectPreciseLow*
MorbidityICU length of stay5 RCTs (n=837)32-35,39LowConsistentDirectPreciseModerate**

ABT = antibiotic; GRADE = grading of recommendations assessment, development, and evaluation; ICU = intensive care unit; RCT = randomized controlled trial

*

The overall grade was low based on uncertainty about the appropriate minimum important difference for assessing noninferiority with respect to mortality.

**

Only three studies reported sufficient details for pooling into a meta-analysis for this outcome.

The overall grade was low based on uncertainty about the appropriate minimum important difference for assessing noninferiority with respect to mortality.

Only three studies reported sufficient details for pooling into a meta-analysis for this outcome.

From: Results

Cover of Procalcitonin-Guided Antibiotic Therapy
Procalcitonin-Guided Antibiotic Therapy [Internet].
Comparative Effectiveness Reviews, No. 78.
Soni NJ, Samson DJ, Galaydick JL, et al.

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