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Table 16Procalcitonin-guided antibiotic initiation and/or discontinuation in patients with respiratory tract infections––mortality

OutcomeAuthor, YearNPCTControlAbsolute Difference PCT-CTRL (95% CI)p-Value
6-month mortalityStolz, 2007382085/102 (4.9%)9/106 (8.5%)-3.6% (-10.3 to 3.2)0.30
6-week mortalityChrist-Crain, 20063630218/151 (11.9%)20/151 (13.2%)-1.3% (-8.8 to 6.2)0.73
≤28-day mortalityChrist-Crain, 2004372434/124(3.2%)4/119 (3.4%)-0.1% (-4.6 to 4.4)0.95
Schuetz, 2009 (30-day)40135934/671(5.1%)33/688(4.8%)0.3% (-2.1 to 2.5)0.82
Briel, 2008424580/231(0%)1/224 (0.4%)-0.4% (-1.3 to 0.4)0.31
Burkhardt, 2010275500/275(0%)0/275 (0%)0--
Kristoffersen, 2009412102/103(1.9%)1/107 (0.9%)1.0% (-2.2 to 4.2)0.54
Long, 2011311620/81 (0%)0/81 (0%)0--

CI = confidence interval; CTRL = control; PCT = procalcitonin

Note: All studies performed intention-to-treat analyses.

From: Results

Cover of Procalcitonin-Guided Antibiotic Therapy
Procalcitonin-Guided Antibiotic Therapy [Internet].
Comparative Effectiveness Reviews, No. 78.
Soni NJ, Samson DJ, Galaydick JL, et al.

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