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TABLE 64Meta-analysis of agreement between Perkins and GAT (mmHg unless otherwise stated)

Description of analysisNo. of studiesNo. of eyesMean difference (Perkins – GAT)95% CII2Random error95% CII295% LoA
Main analysis of mean difference and random error
Random-effects model with mean correlation4504−1.2−2.8 to 0.499%2.11.3 to 2.897%−5.2 to 2.8
Sensitivity analyses
Model type and imputation method
Random-effects model with minimum correlationNot applicable – no imputation required
Fixed-effects model with mean correlation4504−0.4−0.5 to −0.299%1.81.7 to 1.997%−3.9 to 3.2
Fixed-effects model with minimum correlationNot applicable – no imputation required
Additional exclusion criteria
Main analysis excluding low-quality studiesNot applicable – no low-quality studies
Main analysis excluding multiple eye studies33600.0−0.4 to 0.371%1.51.1 to 2.089%−3.0 to 3.0
SMD
Main analysis with SMD33600.0−0.1 to 0.170%
Main analysis of mean difference excluding studies in which SMD was not calculable33600.0−0.4 to 0.371%
Adjustment for repeated measurements: not applicable as no studies reported relevant results for repeatability
Clinical factors analyses
IOP: not applicable as all studies have < 33% of patients with IOP > 21 mmHg
CCT: not applicable as all studies reporting CCT have > 33% of patients with CCT < 555 μm
Refractive surgery: not applicable as no studies have operative patients
Examiner type: not applicable as no studies have ophthalmologist examiners
Manufacturer: not applicable as all Perkins tonometers in the review were manufactured by Kowa

From: Appendix 4, Systematic review of the agreement and reliability of tonometers: further analysis (Chapter 5)

Cover of Surveillance for Ocular Hypertension: An Evidence Synthesis and Economic Evaluation
Surveillance for Ocular Hypertension: An Evidence Synthesis and Economic Evaluation.
Health Technology Assessment, No. 16.29.
Burr JM, Botello-Pinzon P, Takwoingi Y, et al.
© 2012, Crown Copyright.

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