TABLE 14Summary of OS in patients taking TAM in relation to CYP2D6 status: PM versus EM + IM

Cohort/studyAlleles testedOutcome definitionSummary of findings
Goetz et al. cohort:83

Goetz et al. 200584
*4, *6

Only * 4 used for the analysis
Time from registration to death from any causeCox HR (unadjusted):

HR 1.73; 95% CI 0.79 to 3.76; p = 0.169

Cox HR (adjusted for tumour size and nodal status):

HR 1.12; 95% CI 0.50 to 2.50; p = 0.78
Newman et al. 200891*3, *4, *5, *41Not reportedCox HR (adjusted for nodal status):

HR 2.5; 95% CI 0.8 to 8.2; p = 0.17

BRCA1

 HR 0; 95% CI NA; p= 0.18

BRCA2

 HR 9.7; 95% CI 2.3 to 41.0; p= 0.008
Goetz et al. 200982 on behalf of the ITPC; n = 2880aVaries by ITPC site but all genotyped for *4 and the majority genotyped for *3, *5, *6, *10, *17, *41

1168/2880 tested for

*1–*10AB, *11, *14A, *14B, *15, *17, *19, *20, *25, *26, *29–*31, *35, *36, *40, *41, *1 × N, *2 × N, *4 × N, *10 × N, *17 × N, *35 × N, *41 × N
Not reportedNot known

Cox HR adjusted for positive nodes and project sites:

HR 0.92 (p = 0.50)

N, number of copies of the allele; NA, not applicable.

a

Data taken from Microsoft PowerPoint presentation given at the 32nd Annual San Antonio Breast Cancer Symposium, San Antonio, TX, 11 December 2009.

Data taken from Microsoft PowerPoint presentation given at the 32nd Annual San Antonio Breast Cancer Symposium, San Antonio, TX, 11 December 2009.

From: 3, Assessment of clinical effectiveness

Cover of The Clinical Effectiveness and Cost-Effectiveness of Genotyping for CYP2D6 for the Management of Women with Breast Cancer Treated with Tamoxifen: A Systematic Review
The Clinical Effectiveness and Cost-Effectiveness of Genotyping for CYP2D6 for the Management of Women with Breast Cancer Treated with Tamoxifen: A Systematic Review.
Health Technology Assessment, No. 15.33.
Fleeman N, Saborido CM, Payne K, et al.
Southampton (UK): NIHR Journals Library; 2011 Sep.
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