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Table 2-16Summary of study details

PopulationInterventionComparisonOutcomesFollow up
BAINES 198870

Level 1+

N=25
Patients admitted to a special unit for treatment of alcohol dependence, drinking up to the day of admission but not requiring urgent medical treatment and showing the capacity for rehabilitation.Multivitamin supplementation containing 250mg thiamine by single i.m. injection for 5 days

N=8
  1. Oral multivitamin supplementation containing 50mg thiamin 5 times daily for 5 days
    N=8
  2. control group who received no vitamins
    N=9
Erythrocyte thiamine diphosphate (TDP)

(measure of the physiologically active form of thiamine in tissue)
7 days
BROWN
198369

Level 2+

N=97
Patients admitted to the detoxification unit who had not taken vitamin preparations within one month of admission and who had no signs of Wernicke’s encephalopathy. All patients had been drinking in excess of 150cl of alcohol per day and were chemically dependent.Group A: Parentrovite i.v. HP 10ml daily for 5 days (1 dose of parentrovite contains 250mg thiamine HCl)

N=26

By day 5 they had received 1250 ml i.v. thiamine.
Group B: oral orovite 1 tablet 3 times a day for 5 days. (3 tablets of orovite contains 150mg thiamine)

By day 5 they had received 750mg of oral thiamine and 100mg i.v

N=24

Group C: placebo given 3 times per day for 5 days.

N=23
Thiamine, riboflavin, pyridoxine status (via erythrocyte transketolase (ETK), glutathione reductase (EGR) and glutamate- oxaloacetate transaminase (EGOT)5 days

From: 2, Acute Alcohol Withdrawal

Cover of Alcohol Use Disorders
Alcohol Use Disorders: Diagnosis and Clinical Management of Alcohol-Related Physical Complications [Internet].
NICE Clinical Guidelines, No. 100.
National Clinical Guideline Centre (UK).
Copyright © 2010, National Clinical Guidelines Centre.

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