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FIGURE 2. The two-hit theory of NASH.

FIGURE 2The two-hit theory of NASH

This involves insulin resistance, which causes hepatic steatosis, a process enhanced by obesity and/or T2DM. Once developed, hepatic steatosis may remain in a benign state or progress to NASH via the mechanisms discussed. Reproduced with permission from AJ McCullough. Pathophysiology of nonalcoholic steatohepatitis. J Clin Gastroenterol 2006;40(Suppl. 1):17–29.16

From: 1, Introduction

Cover of Insulin Sensitisers in the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review
Insulin Sensitisers in the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review.
Health Technology Assessment, No. 15.38.
Shyangdan D, Clar C, Ghouri N, et al.
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