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Table 61Summary of evidence: ventilation

AssociationMantoux test conversion rates in healthcare workersAssociation/statistical significanceRef and NICE grade
Ventilation in non-isolation rooms and risk of latent TB infectionShorter time to conversion significantly associated with being in a non-isolation room with less than two air exchanges vs. a room with two plus air exchanges per hour.Hazard ratio: 3.4 (95% CI 2.1 to 5.8){377} 3+
Ventilation in respiratory isolation rooms and risk of latent TB infectionNo significant difference in time to conversion for isolation rooms with less than six air exchanges vs. those with six plus air exchanges per hour.Hazard ratio: 1.02 (95% CI 0.8 to 1.3){377} 3+
Inadequate ventilation and risk of latent TB infection in nurses and housekeeping staffRates significantly associated with inadequately ventilated non-isolation and isolation rooms.p<0.001{377} 3+
Inadequate ventilation and risk of latent TB infection in respiratory therapistsRates significantly associated with inadequate ventilated non-isolation and bronchoscopy rooms.p<0.001{377} 3+

From: 13, Preventing infection in specific settings

Cover of Tuberculosis
Tuberculosis: Clinical Diagnosis and Management of Tuberculosis, and Measures for Its Prevention and Control.
NICE Clinical Guidelines, No. 117.
National Collaborating Centre for Chronic Conditions (UK); Centre for Clinical Practice at NICE (UK).
Copyright © 2006, Royal College of Physicians of London.

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