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Table 8Updated/Modified input parameters

Base caseLower limitUpper limitSource
POPULATION AND BASELINE RISKS
Prevalence of infection in cohortprev20%0.010.3GDG consensus
Proportion of infected patients with active diseasepTB0.25%0.10.5GDG consensus
Mean number of secondary cases per primary casenSec0.401GDG consensus
ACCURACY OF TESTS
Sensitivity of Interferon Gamma testsSe0.8650.7630.967Girardi et al
Specificity of Interferon Gamma testsSp0.8960.8560.936Giradi et al
Sensitivity of TSTSeTST0.990.951Girardi et al
Specificity of TSTSpTST0.6420.530.741Girardi et al
COSTS
Cost of contact tracing (£ per case)2, 0584665, 470Various
Cost of outpatient care (£ per active case)7774391, 406Various
Cost of outpatient care (£ per latent case)695350777Various

From: Appendix L, Health economic model - 2011

Cover of Tuberculosis
Tuberculosis: Clinical Diagnosis and Management of Tuberculosis, and Measures for Its Prevention and Control.
NICE Clinical Guidelines, No. 117.
National Collaborating Centre for Chronic Conditions (UK); Centre for Clinical Practice at NICE (UK).
Copyright © 2006, Royal College of Physicians of London. Updated text, Copyright © 2011, National Institute for Health and Clinical Excellence.

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